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Page 1
An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris.
Iyer KR, Camara K, Daniel-Ivad M, Trilles R, Pimentel-Elardo SM, Fossen JL, Marchillo K, Liu Z, Singh S, Muñoz JF, Kim SH, Porco JA Jr, Cuomo CA, Williams NS, Ibrahim AS, Edwards JE Jr, Andes DR, Nodwell JR, Brown LE, Whitesell L, Robbins N, Cowen LE. Iyer KR, et al. Among authors: williams ns. Nat Commun. 2020 Dec 22;11(1):6429. doi: 10.1038/s41467-020-20183-3. Nat Commun. 2020. PMID: 33353950 Free PMC article.
Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity.
Marcyk PT, LeBlanc EV, Kuntz DA, Xue A, Ortiz F, Trilles R, Bengtson S, Kenney TMG, Huang DS, Robbins N, Williams NS, Krysan DJ, Privé GG, Whitesell L, Cowen LE, Brown LE. Marcyk PT, et al. Among authors: williams ns. J Med Chem. 2021 Jan 28;64(2):1139-1169. doi: 10.1021/acs.jmedchem.0c01777. Epub 2021 Jan 14. J Med Chem. 2021. PMID: 33444025 Free PMC article.
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma.
Shi Y, Lim SK, Liang Q, Iyer SV, Wang HY, Wang Z, Xie X, Sun D, Chen YJ, Tabar V, Gutin P, Williams N, De Brabander JK, Parada LF. Shi Y, et al. Nature. 2019 Mar;567(7748):341-346. doi: 10.1038/s41586-019-0993-x. Epub 2019 Mar 6. Nature. 2019. PMID: 30842654 Free PMC article.
A trimethoprim derivative impedes antibiotic resistance evolution.
Manna MS, Tamer YT, Gaszek I, Poulides N, Ahmed A, Wang X, Toprak FCR, Woodard DR, Koh AY, Williams NS, Borek D, Atilgan AR, Hulleman JD, Atilgan C, Tambar U, Toprak E. Manna MS, et al. Among authors: williams ns. Nat Commun. 2021 May 19;12(1):2949. doi: 10.1038/s41467-021-23191-z. Nat Commun. 2021. PMID: 34011959 Free PMC article.
Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis.
Venkateswaran N, Garcia R, Lafita-Navarro MC, Hao YH, Perez-Castro L, Nogueira PAS, Solmonson A, Mender I, Kilgore JA, Fang S, Brown IN, Li L, Parks E, Lopes Dos Santos I, Bhaskar M, Kim J, Jia Y, Lemoff A, Grishin NV, Kinch L, Xu L, Williams NS, Shay JW, DeBerardinis RJ, Zhu H, Conacci-Sorrell M. Venkateswaran N, et al. Among authors: williams ns. Nat Commun. 2024 May 20;15(1):4266. doi: 10.1038/s41467-024-47868-3. Nat Commun. 2024. PMID: 38769298 Free PMC article.
Targeting QseC signaling and virulence for antibiotic development.
Rasko DA, Moreira CG, Li de R, Reading NC, Ritchie JM, Waldor MK, Williams N, Taussig R, Wei S, Roth M, Hughes DT, Huntley JF, Fina MW, Falck JR, Sperandio V. Rasko DA, et al. Science. 2008 Aug 22;321(5892):1078-80. doi: 10.1126/science.1160354. Science. 2008. PMID: 18719281 Free PMC article.
Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor.
Mata MA, Satterly N, Versteeg GA, Frantz D, Wei S, Williams N, Schmolke M, Peña-Llopis S, Brugarolas J, Forst CV, White MA, García-Sastre A, Roth MG, Fontoura BM. Mata MA, et al. Nat Chem Biol. 2011 Sep 11;7(10):712-9. doi: 10.1038/nchembio.645. Nat Chem Biol. 2011. PMID: 21909097 Free PMC article.
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase.
Theodoropoulos PC, Gonzales SS, Winterton SE, Rodriguez-Navas C, McKnight JS, Morlock LK, Hanson JM, Cross B, Owen AE, Duan Y, Moreno JR, Lemoff A, Mirzaei H, Posner BA, Williams NS, Ready JM, Nijhawan D. Theodoropoulos PC, et al. Among authors: williams ns. Nat Chem Biol. 2016 Apr;12(4):218-25. doi: 10.1038/nchembio.2016. Epub 2016 Feb 1. Nat Chem Biol. 2016. PMID: 26829472 Free PMC article.
422 results