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Derivation of familial iPSC lines from three ASD patients carrying NRXN1α+/- and two controls (NUIGi022-A, NUIGi022-B; NUIGi023-A, NUIGi023-B; NUIGi025-A, NUIGi025-B; NUIGi024-A, NUIGi024-B; NUIGi026-A, NUIGi026-B).
Ding Y, Marcó de la Cruz B, Xia Y, Liu M, Lu Y, McInerney V, Krawczyk J, Lynch SA, Howard L, O'Brien T, Gallagher L, Shen S. Ding Y, et al. Among authors: lu y. Stem Cell Res. 2019 Dec;41:101653. doi: 10.1016/j.scr.2019.101653. Epub 2019 Nov 13. Stem Cell Res. 2019. PMID: 31759289 Free article.
Derivation of four iPSC lines from a male ASD patient carrying a deletion in the middle coding region of NRXN1α gene (NUIGi039-A and NUIGi039-B) and a male sibling control (NUIGi040-A and NUIGi040-B).
Ding Y, O'Brien A, Marcó de la Cruz B, Yang M, Lu Y, Qian X, Yang G, McInerney V, Krawczyk J, Lynch SA, Howard L, Allen NM, O'Brien T, Gallagher L, Shen S. Ding Y, et al. Among authors: lu y. Stem Cell Res. 2021 May;53:102254. doi: 10.1016/j.scr.2021.102254. Epub 2021 Feb 18. Stem Cell Res. 2021. PMID: 33631419 Free article.
NRXN1α+/- is associated with increased excitability in ASD iPSC-derived neurons.
Avazzadeh S, Quinlan LR, Reilly J, McDonagh K, Jalali A, Wang Y, McInerney V, Krawczyk J, Ding Y, Fitzgerald J, O'Sullivan M, Forman EB, Lynch SA, Ennis S, Feerick N, Reilly R, Li W, Shen X, Yang G, Lu Y, Peeters H, Dockery P, O'Brien T, Shen S, Gallagher L. Avazzadeh S, et al. Among authors: lu y. BMC Neurosci. 2021 Sep 15;22(1):56. doi: 10.1186/s12868-021-00661-0. BMC Neurosci. 2021. PMID: 34525970 Free PMC article.
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