Pabst TM - Search Results

1

Safety risk management for low molecular weight process-related impurities in monoclonal antibody therapeutics: Categorization, risk assessment, testing strategy, and process development with leveraging clearance potential.

Luo H, Li Y, Robbins D, Wang SC, Xi G, Cox M, Nicholson SM, Wei C, Pabst TM, Wang WK. Luo H, et al. Among authors: pabst tm. Biotechnol Prog. 2021 May;37(3):e3119. doi: 10.1002/btpr.3119. Epub 2021 Jan 6. Biotechnol Prog. 2021. PMID: 33373106 Free PMC article.

2

Liquid-liquid phase separation causes high turbidity and pressure during low pH elution process in Protein A chromatography.

Luo H, Lee N, Wang X, Li Y, Schmelzer A, Hunter AK, Pabst T, Wang WK. Luo H, et al. J Chromatogr A. 2017 Mar 10;1488:57-67. doi: 10.1016/j.chroma.2017.01.067. Epub 2017 Jan 28. J Chromatogr A. 2017. PMID: 28159365 Free article.

3

Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions.

Du Q, Damschroder M, Pabst TM, Hunter AK, Wang WK, Luo H. Du Q, et al. Among authors: pabst tm. MAbs. 2019 May/Jun;11(4):789-802. doi: 10.1080/19420862.2019.1599634. Epub 2019 Apr 14. MAbs. 2019. PMID: 30913985 Free PMC article.

4

Development and scale-up of a commercial fed batch refolding process for an anti-CD22 two chain immunotoxin.

Linke T, Aspelund MT, Thompson C, Xi G, Fulton A, Wendeler M, Pabst TM, Wang X, Wang WK, Ram K, Hunter AK. Linke T, et al. Among authors: pabst tm. Biotechnol Prog. 2014 Nov-Dec;30(6):1380-9. doi: 10.1002/btpr.1983. Epub 2014 Sep 2. Biotechnol Prog. 2014. PMID: 25139260 Free PMC article.

5

Cathepsin L Causes Proteolytic Cleavage of Chinese-Hamster-Ovary Cell Expressed Proteins During Processing and Storage: Identification, Characterization, and Mitigation.

Luo H, Tie L, Cao M, Hunter AK, Pabst TM, Du J, Field R, Li Y, Wang WK. Luo H, et al. Among authors: pabst tm. Biotechnol Prog. 2019 Jan;35(1):e2732. doi: 10.1002/btpr.2732. Epub 2018 Nov 4. Biotechnol Prog. 2019. PMID: 30320962 Free PMC article.

6

Formation of transient highly-charged mAb clusters strengthens interactions with host cell proteins and results in poor clearance of host cell proteins by protein A chromatography.

Luo H, Du Q, Qian C, Mlynarczyk M, Pabst TM, Damschroder M, Hunter AK, Wang WK. Luo H, et al. Among authors: pabst tm. J Chromatogr A. 2022 Aug 30;1679:463385. doi: 10.1016/j.chroma.2022.463385. Epub 2022 Jul 30. J Chromatogr A. 2022. PMID: 35933770

7

Engineering of novel Staphylococcal Protein A ligands to enable milder elution pH and high dynamic binding capacity.

Pabst TM, Palmgren R, Forss A, Vasic J, Fonseca M, Thompson C, Wang WK, Wang X, Hunter AK. Pabst TM, et al. J Chromatogr A. 2014 Oct 3;1362:180-5. doi: 10.1016/j.chroma.2014.08.046. Epub 2014 Aug 19. J Chromatogr A. 2014. PMID: 25193170 Free article.

8

Camelid V_H H affinity ligands enable separation of closely related biopharmaceuticals.

Pabst TM, Wendeler M, Wang X, Bezemer S, Hermans P, Hunter AK. Pabst TM, et al. Biotechnol J. 2017 Feb;12(2):1600357. doi: 10.1002/biot.201600357. Epub 2016 Oct 20. Biotechnol J. 2017. PMID: 27677057 Free PMC article.

9

Evaluation of recent Protein A stationary phase innovations for capture of biotherapeutics.

Pabst TM, Thai J, Hunter AK. Pabst TM, et al. J Chromatogr A. 2018 Jun 15;1554:45-60. doi: 10.1016/j.chroma.2018.03.060. Epub 2018 Apr 7. J Chromatogr A. 2018. PMID: 29685337 Free article.

10

Separation of antibody monomer-dimer mixtures by frontal analysis.

Reck JM, Pabst TM, Hunter AK, Carta G. Reck JM, et al. Among authors: pabst tm. J Chromatogr A. 2017 Jun 2;1500:96-104. doi: 10.1016/j.chroma.2017.04.014. Epub 2017 Apr 10. J Chromatogr A. 2017. PMID: 28420529

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