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Multi-omic molecular profiling reveals potentially targetable abnormalities shared across multiple histologies of brain metastasis.
Fukumura K, Malgulwar PB, Fischer GM, Hu X, Mao X, Song X, Hernandez SD, Zhang XH, Zhang J, Parra ER, Yu D, Debeb BG, Davies MA, Huse JT. Fukumura K, et al. Among authors: yu d. Acta Neuropathol. 2021 Feb;141(2):303-321. doi: 10.1007/s00401-020-02256-1. Epub 2021 Jan 4. Acta Neuropathol. 2021. PMID: 33394124 Free PMC article.
14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.
Xu J, Acharya S, Sahin O, Zhang Q, Saito Y, Yao J, Wang H, Li P, Zhang L, Lowery FJ, Kuo WL, Xiao Y, Ensor J, Sahin AA, Zhang XH, Hung MC, Zhang JD, Yu D. Xu J, et al. Among authors: yu d. Cancer Cell. 2015 Feb 9;27(2):177-92. doi: 10.1016/j.ccell.2014.11.025. Cancer Cell. 2015. PMID: 25670079 Free PMC article.
Advances in decoding breast cancer brain metastasis.
Zhang C, Yu D. Zhang C, et al. Among authors: yu d. Cancer Metastasis Rev. 2016 Dec;35(4):677-684. doi: 10.1007/s10555-016-9638-9. Cancer Metastasis Rev. 2016. PMID: 27873078 Free PMC article. Review.
Brain metastasis: Unique challenges and open opportunities.
Lowery FJ, Yu D. Lowery FJ, et al. Among authors: yu d. Biochim Biophys Acta Rev Cancer. 2017 Jan;1867(1):49-57. doi: 10.1016/j.bbcan.2016.12.001. Epub 2016 Dec 6. Biochim Biophys Acta Rev Cancer. 2017. PMID: 27939792 Free PMC article. Review.
Brain Metastasis Organotropism.
Yuzhalin AE, Yu D. Yuzhalin AE, et al. Among authors: yu d. Cold Spring Harb Perspect Med. 2020 May 1;10(5):a037242. doi: 10.1101/cshperspect.a037242. Cold Spring Harb Perspect Med. 2020. PMID: 31548224 Free PMC article. Review.
Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases.
Zhang L, Yao J, Wei Y, Zhou Z, Li P, Qu J, Badu-Nkansah A, Yuan X, Huang YW, Fukumura K, Mao X, Chang WC, Saunus J, Lakhani S, Huse JT, Hung MC, Yu D. Zhang L, et al. Among authors: yu d. Sci Transl Med. 2020 May 27;12(545):eaaz5387. doi: 10.1126/scitranslmed.aaz5387. Sci Transl Med. 2020. PMID: 32461334 Free PMC article.
Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition.
Yuzhalin AE, Lowery FJ, Saito Y, Yuan X, Yao J, Duan Y, Ding J, Acharya S, Zhang C, Fajardo A, Chen HN, Wei Y, Sun Y, Zhang L, Xiao Y, Li P, Lorenzi PL, Huse JT, Fan H, Zhao Z, Hung MC, Yu D. Yuzhalin AE, et al. Among authors: yu d. Nat Cell Biol. 2024 Oct;26(10):1773-1789. doi: 10.1038/s41556-024-01509-5. Epub 2024 Sep 20. Nat Cell Biol. 2024. PMID: 39304713
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