Brown WC - Search Results

1

Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction.

Biering SB, Akey DL, Wong MP, Brown WC, Lo NTN, Puerta-Guardo H, Tramontini Gomes de Sousa F, Wang C, Konwerski JR, Espinosa DA, Bockhaus NJ, Glasner DR, Li J, Blanc SF, Juan EY, Elledge SJ, Mina MJ, Beatty PR, Smith JL, Harris E. Biering SB, et al. Among authors: brown wc. Science. 2021 Jan 8;371(6525):194-200. doi: 10.1126/science.abc0476. Science. 2021. PMID: 33414220 Free PMC article.

2

Flavivirus NS1 structures reveal surfaces for associations with membranes and the immune system.

Akey DL, Brown WC, Dutta S, Konwerski J, Jose J, Jurkiw TJ, DelProposto J, Ogata CM, Skiniotis G, Kuhn RJ, Smith JL. Akey DL, et al. Among authors: brown wc. Science. 2014 Feb 21;343(6173):881-5. doi: 10.1126/science.1247749. Epub 2014 Feb 6. Science. 2014. PMID: 24505133 Free PMC article.

3

Use of massively multiple merged data for low-resolution S-SAD phasing and refinement of flavivirus NS1.

Akey DL, Brown WC, Konwerski JR, Ogata CM, Smith JL. Akey DL, et al. Among authors: brown wc. Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2719-29. doi: 10.1107/S1399004714017556. Epub 2014 Sep 27. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 25286855 Free PMC article.

4

Structure-guided insights on the role of NS1 in flavivirus infection.

Akey DL, Brown WC, Jose J, Kuhn RJ, Smith JL. Akey DL, et al. Among authors: brown wc. Bioessays. 2015 May;37(5):489-94. doi: 10.1002/bies.201400182. Epub 2015 Mar 11. Bioessays. 2015. PMID: 25761098 Free PMC article.

5

Extended surface for membrane association in Zika virus NS1 structure.

Brown WC, Akey DL, Konwerski JR, Tarrasch JT, Skiniotis G, Kuhn RJ, Smith JL. Brown WC, et al. Nat Struct Mol Biol. 2016 Sep;23(9):865-7. doi: 10.1038/nsmb.3268. Epub 2016 Jul 25. Nat Struct Mol Biol. 2016. PMID: 27455458 Free PMC article.

6

Crystal structures capture three states in the catalytic cycle of a pyridoxal phosphate (PLP) synthase.

Smith AM, Brown WC, Harms E, Smith JL. Smith AM, et al. Among authors: brown wc. J Biol Chem. 2015 Feb 27;290(9):5226-39. doi: 10.1074/jbc.M114.626382. Epub 2015 Jan 7. J Biol Chem. 2015. PMID: 25568319 Free PMC article.

7

Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis.

Whicher JR, Smaga SS, Hansen DA, Brown WC, Gerwick WH, Sherman DH, Smith JL. Whicher JR, et al. Among authors: brown wc. Chem Biol. 2013 Nov 21;20(11):1340-51. doi: 10.1016/j.chembiol.2013.09.015. Epub 2013 Oct 31. Chem Biol. 2013. PMID: 24183970 Free PMC article.

8

Mocr: a novel fusion tag for enhancing solubility that is compatible with structural biology applications.

DelProposto J, Majmudar CY, Smith JL, Brown WC. DelProposto J, et al. Among authors: brown wc. Protein Expr Purif. 2009 Jan;63(1):40-9. doi: 10.1016/j.pep.2008.08.011. Epub 2008 Sep 12. Protein Expr Purif. 2009. PMID: 18824232 Free PMC article.

9

APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA.

Bohn JA, Thummar K, York A, Raymond A, Brown WC, Bieniasz PD, Hatziioannou T, Smith JL. Bohn JA, et al. Among authors: brown wc. Nat Commun. 2017 Oct 18;8(1):1021. doi: 10.1038/s41467-017-01309-6. Nat Commun. 2017. PMID: 29044109 Free PMC article.

10

Structure and activity of DmmA, a marine haloalkane dehalogenase.

Gehret JJ, Gu L, Geders TW, Brown WC, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Gehret JJ, et al. Among authors: brown wc. Protein Sci. 2012 Feb;21(2):239-48. doi: 10.1002/pro.2009. Epub 2012 Jan 4. Protein Sci. 2012. PMID: 22124946 Free PMC article.

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