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Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2'-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide-Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6.
Zanardi TA, Korbmacher B, Boone L, Engelhardt JA, Wang Y, Burel S, Prill B, Aghajan M, Guo S, Henry SP. Zanardi TA, et al. Among authors: wang y. J Pharmacol Exp Ther. 2021 Apr;377(1):51-63. doi: 10.1124/jpet.120.000222. Epub 2021 Jan 11. J Pharmacol Exp Ther. 2021. PMID: 33431610
Lack of QT Prolongation for 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlled Studies in Healthy Subjects.
Yu RZ, Gunawan R, Geary RS, Hughes SG, Henry SP, Wang Y. Yu RZ, et al. Among authors: wang y. Nucleic Acid Ther. 2017 Oct;27(5):285-294. doi: 10.1089/nat.2017.0676. Epub 2017 Aug 11. Nucleic Acid Ther. 2017. PMID: 28799823 Free PMC article. Clinical Trial.
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