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Page 1
ODYSSEY clinical trial design: a randomised global study to evaluate the efficacy and safety of dolutegravir-based antiretroviral therapy in HIV-positive children, with nested pharmacokinetic sub-studies to evaluate pragmatic WHO-weight-band based dolutegravir dosing.
Moore CL, Turkova A, Mujuru H, Kekitiinwa A, Lugemwa A, Kityo CM, Barlow-Mosha LN, Cressey TR, Violari A, Variava E, Cotton MF, Archary M, Compagnucci A, Puthanakit T, Behuhuma O, Saϊdi Y, Hakim J, Amuge P, Atwine L, Musiime V, Burger DM, Shakeshaft C, Giaquinto C, Rojo P, Gibb DM, Ford D; ODYSSEY Trial Team. Moore CL, et al. Among authors: behuhuma o. BMC Infect Dis. 2021 Jan 4;21(1):5. doi: 10.1186/s12879-020-05672-6. BMC Infect Dis. 2021. PMID: 33446115 Free PMC article. Clinical Trial.
Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children.
Turkova A, White E, Mujuru HA, Kekitiinwa AR, Kityo CM, Violari A, Lugemwa A, Cressey TR, Musoke P, Variava E, Cotton MF, Archary M, Puthanakit T, Behuhuma O, Kobbe R, Welch SB, Bwakura-Dangarembizi M, Amuge P, Kaudha E, Barlow-Mosha L, Makumbi S, Ramsagar N, Ngampiyaskul C, Musoro G, Atwine L, Liberty A, Musiime V, Bbuye D, Ahimbisibwe GM, Chalermpantmetagul S, Ali S, Sarfati T, Wynne B, Shakeshaft C, Colbers A, Klein N, Bernays S, Saïdi Y, Coelho A, Grossele T, Compagnucci A, Giaquinto C, Rojo P, Ford D, Gibb DM; ODYSSEY Trial Team. Turkova A, et al. Among authors: behuhuma o. N Engl J Med. 2021 Dec 30;385(27):2531-2543. doi: 10.1056/NEJMoa2108793. N Engl J Med. 2021. PMID: 34965338 Free PMC article. Clinical Trial.
Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial.
Turkova A, White E, Kekitiinwa AR, Mumbiro V, Kaudha E, Liberty A, Ahimbisibwe GM, Moloantoa T, Srirompotong U, Mosia NR, Puthanakit T, Kobbe R, Fortuny C, Kataike H, Bbuye D, Na-Rajsima S, Coelho A, Lugemwa A, Bwakura-Dangarembizi MF, Klein N, Mujuru HA, Kityo C, Cotton MF, Ferrand RA, Giaquinto C, Rojo P, Violari A, Gibb DM, Ford D; ODYSSEY trial team. Turkova A, et al. Lancet Child Adolesc Health. 2023 Oct;7(10):718-727. doi: 10.1016/S2352-4642(23)00164-5. Epub 2023 Aug 8. Lancet Child Adolesc Health. 2023. PMID: 37562418 Free PMC article. Clinical Trial.
Early inflammation as a footprint of increased mortality risk in infants living with HIV from three African countries.
Morrocchi E, Pascucci GR, Cotugno N, Pighi C, Dominguez-Rodriguez S, Petrara MR, Tagarro A, Kuhn L, Cotton MF, Otwombe K, Lain MG, Vaz P, Barnabas SL, Spyer MJ, Lopez E, Fernández-Luis S, Nhampossa T, Maiga AI, Dolo O, De Rossi A, Rojo P, Giaquinto C, Lichterfeld M, Violari A, Smit T, Behuhuma O, Klein N, De Armas L, Pahwa S, Rossi P, Palma P; EPIICAL consortium. Morrocchi E, et al. Among authors: behuhuma o. Sci Rep. 2024 Oct 28;14(1):25792. doi: 10.1038/s41598-024-74066-4. Sci Rep. 2024. PMID: 39468166 Free PMC article.
High mortality following early initiation of antiretroviral therapy in infants living with HIV from three African countries.
Tagarro A, Domínguez-Rodríguez S, Cotton M, Otwombe K, Klein N, Lain MG, Nhampossa T, Maiga AI, Barnabas S, Vaz P, Violari A, Fernández-Luis S, Behuhuma O, Sylla M, López-Varela E, Naniche D, Janse-Van-Rensburg A, Liberty A, Ramsagar N, Smit T, Makhari S, Ismael N, Giaquinto C, Rossi P, Kuhn L, Palma P, Spyer M, Lichterfeld M, Nastuoli E, Giannuzzi V, Ballesteros A, Cotugno N, Morrocchi E, Oletto A, Traoré FT, Dobbels E, Akhalwaya Y, Ording-Jespersen G, Foster C, Rabie H, Amuge P, Brehin C, Pahwa S, Coulibaly YA, Rojo P; EPIICAL Consortium. Tagarro A, et al. Among authors: behuhuma o. EClinicalMedicine. 2024 May 23;73:102648. doi: 10.1016/j.eclinm.2024.102648. eCollection 2024 Jul. EClinicalMedicine. 2024. PMID: 39411486 Free PMC article.
eYoung men's experiences of violence and poverty and the relationship to sexually transmissible HIV: a cross sectional study from rural South Africa.
Gibbs A, Chirwa E, Harling G, Chimbindi N, Dreyer J, Herbst C, Okesola N, Behuhuma O, Mthiyane N, Baisley K, Zuma T, Smit T, McGrath N, Sherr L, Seeley J, Shahmanesh M. Gibbs A, et al. Among authors: behuhuma o. medRxiv [Preprint]. 2024 Sep 9:2024.09.08.24313251. doi: 10.1101/2024.09.08.24313251. medRxiv. 2024. PMID: 39314958 Free PMC article. Preprint.
Machine learning outperformed logistic regression classification even with limit sample size: A model to predict pediatric HIV mortality and clinical progression to AIDS.
Domínguez-Rodríguez S, Serna-Pascual M, Oletto A, Barnabas S, Zuidewind P, Dobbels E, Danaviah S, Behuhuma O, Lain MG, Vaz P, Fernández-Luis S, Nhampossa T, Lopez-Varela E, Otwombe K, Liberty A, Violari A, Maiga AI, Rossi P, Giaquinto C, Kuhn L, Rojo P, Tagarro A; EPIICAL Consortium. Domínguez-Rodríguez S, et al. Among authors: behuhuma o. PLoS One. 2022 Oct 14;17(10):e0276116. doi: 10.1371/journal.pone.0276116. eCollection 2022. PLoS One. 2022. PMID: 36240212 Free PMC article.
Once-daily dolutegravir-based antiretroviral therapy in infants and children living with HIV from age 4 weeks: results from the below 14 kg cohort in the randomised ODYSSEY trial.
Amuge P, Lugemwa A, Wynne B, Mujuru HA, Violari A, Kityo CM, Archary M, Variava E, White E, Turner RM, Shakeshaft C, Ali S, Nathoo KJ, Atwine L, Liberty A, Bbuye D, Kaudha E, Mngqibisa R, Mosala M, Mumbiro V, Nanduudu A, Ankunda R, Maseko L, Kekitiinwa AR, Giaquinto C, Rojo P, Gibb DM, Turkova A, Ford D; ODYSSEY Trial Team. Amuge P, et al. Lancet HIV. 2022 Sep;9(9):e638-e648. doi: 10.1016/S2352-3018(22)00163-1. Lancet HIV. 2022. PMID: 36055295 Free PMC article. Clinical Trial.
Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial.
Turkova A, Waalewijn H, Chan MK, Bollen PDJ, Bwakura-Dangarembizi MF, Kekitiinwa AR, Cotton MF, Lugemwa A, Variava E, Ahimbisibwe GM, Srirompotong U, Mumbiro V, Amuge P, Zuidewind P, Ali S, Kityo CM, Archary M, Ferrand RA, Violari A, Gibb DM, Burger DM, Ford D, Colbers A; ODYSSEY Trial Team. Turkova A, et al. Lancet HIV. 2022 Sep;9(9):e627-e637. doi: 10.1016/S2352-3018(22)00160-6. Epub 2022 Jul 19. Lancet HIV. 2022. PMID: 35868341 Free PMC article. Clinical Trial.
Optimizing the World Health Organization algorithm for HIV vertical transmission risk assessment by adding maternal self-reported antiretroviral therapy adherence.
Fernández-Luis S, Lain MG, Serna-Pascual M, Domínguez-Rodríguez S, Kuhn L, Liberty A, Barnabas S, Lopez-Varela E, Otwombe K, Danaviah S, Nastouli E, Palma P, Cotugno N, Spyer M, Giannuzzi V, Giaquinto C, Violari A, Cotton MF, Nhampossa T, Klein N, Ramsagar N, van Rensburg AJ, Behuhuma O, Vaz P, Maiga AI, Oletto A, Naniche D, Rossi P, Rojo P, Tagarro A; EPIICAL Consortium. Fernández-Luis S, et al. Among authors: behuhuma o. BMC Public Health. 2022 Jul 8;22(1):1312. doi: 10.1186/s12889-022-13543-9. BMC Public Health. 2022. PMID: 35804333 Free PMC article.