Burk O - Search Results

1

Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor.

Burk O, Kronenberger T, Keminer O, Lee SML, Schiergens TS, Schwab M, Windshügel B. Burk O, et al. Mol Pharmacol. 2021 Mar;99(3):184-196. doi: 10.1124/molpharm.120.000116. Epub 2021 Jan 22. Mol Pharmacol. 2021. PMID: 33483427

2

Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.

Jeske J, Windshügel B, Thasler WE, Schwab M, Burk O. Jeske J, et al. Among authors: burk o. Arch Toxicol. 2017 Jun;91(6):2375-2390. doi: 10.1007/s00204-017-1948-3. Epub 2017 Mar 13. Arch Toxicol. 2017. PMID: 28289823

3

Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3.

Keminer O, Windshügel B, Essmann F, Lee SML, Schiergens TS, Schwab M, Burk O. Keminer O, et al. Among authors: burk o. Arch Toxicol. 2019 Aug;93(8):2247-2264. doi: 10.1007/s00204-019-02495-6. Epub 2019 Jul 16. Arch Toxicol. 2019. PMID: 31312845

4

Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor.

Jeske J, Bitter A, Thasler WE, Weiss TS, Schwab M, Burk O. Jeske J, et al. Among authors: burk o. Biochem Pharmacol. 2017 Jul 15;136:122-135. doi: 10.1016/j.bcp.2017.04.013. Epub 2017 Apr 13. Biochem Pharmacol. 2017. PMID: 28414139

5

Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.

Burk O, Kuzikov M, Kronenberger T, Jeske J, Keminer O, Thasler WE, Schwab M, Wrenger C, Windshügel B. Burk O, et al. Arch Toxicol. 2018 Apr;92(4):1435-1451. doi: 10.1007/s00204-018-2165-4. Epub 2018 Jan 22. Arch Toxicol. 2018. PMID: 29356861

6

Differential effects of clinically used derivatives and metabolites of artemisinin in the activation of constitutive androstane receptor isoforms.

Burk O, Piedade R, Ghebreghiorghis L, Fait JT, Nussler AK, Gil JP, Windshügel B, Schwab M. Burk O, et al. Br J Pharmacol. 2012 Oct;167(3):666-81. doi: 10.1111/j.1476-5381.2012.02033.x. Br J Pharmacol. 2012. PMID: 22577882 Free PMC article.

7

Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα).

Thomas M, Burk O, Klumpp B, Kandel BA, Damm G, Weiss TS, Klein K, Schwab M, Zanger UM. Thomas M, et al. Among authors: burk o. Mol Pharmacol. 2013 Mar;83(3):709-18. doi: 10.1124/mol.112.082503. Epub 2013 Jan 7. Mol Pharmacol. 2013. PMID: 23295386

8

Structural and functional similarity of amphibian constitutive androstane receptor with mammalian pregnane X receptor.

Mathäs M, Nusshag C, Burk O, Gödtel-Armbrust U, Herlyn H, Wojnowski L, Windshügel B. Mathäs M, et al. Among authors: burk o. PLoS One. 2014 May 5;9(5):e96263. doi: 10.1371/journal.pone.0096263. eCollection 2014. PLoS One. 2014. PMID: 24797902 Free PMC article.

9

Pregnane X receptor activation and silencing promote steatosis of human hepatic cells by distinct lipogenic mechanisms.

Bitter A, Rümmele P, Klein K, Kandel BA, Rieger JK, Nüssler AK, Zanger UM, Trauner M, Schwab M, Burk O. Bitter A, et al. Among authors: burk o. Arch Toxicol. 2015 Nov;89(11):2089-103. doi: 10.1007/s00204-014-1348-x. Epub 2014 Sep 3. Arch Toxicol. 2015. PMID: 25182422

10

Carboxymefloquine, the major metabolite of the antimalarial drug mefloquine, induces drug-metabolizing enzyme and transporter expression by activation of pregnane X receptor.

Piedade R, Traub S, Bitter A, Nüssler AK, Gil JP, Schwab M, Burk O. Piedade R, et al. Among authors: burk o. Antimicrob Agents Chemother. 2015 Jan;59(1):96-104. doi: 10.1128/AAC.04140-14. Epub 2014 Oct 13. Antimicrob Agents Chemother. 2015. PMID: 25313206 Free PMC article.

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