Berk C - Search Results

1

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA.

Villiger L, Rothgangl T, Witzigmann D, Oka R, Lin PJC, Qi W, Janjuha S, Berk C, Ringnalda F, Beattie MB, Stoffel M, Thöny B, Hall J, Rehrauer H, van Boxtel R, Tam YK, Schwank G. Villiger L, et al. Among authors: berk c. Nat Biomed Eng. 2021 Feb;5(2):179-189. doi: 10.1038/s41551-020-00671-z. Epub 2021 Jan 25. Nat Biomed Eng. 2021. PMID: 33495639 Free PMC article.

2

Type III CRISPR-Cas systems produce cyclic oligoadenylate second messengers.

Niewoehner O, Garcia-Doval C, Rostøl JT, Berk C, Schwede F, Bigler L, Hall J, Marraffini LA, Jinek M. Niewoehner O, et al. Among authors: berk c. Nature. 2017 Aug 31;548(7669):543-548. doi: 10.1038/nature23467. Epub 2017 Jul 19. Nature. 2017. PMID: 28722012

3

Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair.

Savic N, Ringnalda FC, Lindsay H, Berk C, Bargsten K, Li Y, Neri D, Robinson MD, Ciaudo C, Hall J, Jinek M, Schwank G. Savic N, et al. Among authors: berk c. Elife. 2018 May 29;7:e33761. doi: 10.7554/eLife.33761. Elife. 2018. PMID: 29809142 Free PMC article.

4

In vitro Generation of CRISPR-Cas9 Complexes with Covalently Bound Repair Templates for Genome Editing in Mammalian Cells.

Savić N, Ringnalda FC, Berk C, Bargsten K, Hall J, Jinek M, Schwank G. Savić N, et al. Among authors: berk c. Bio Protoc. 2019 Jan 5;9(1):e3136. doi: 10.21769/BioProtoc.3136. Bio Protoc. 2019. PMID: 30675496 Free PMC article.

5

RNA Chemistry for RNA Biology.

Röthlisberger P, Berk C, Hall J. Röthlisberger P, et al. Among authors: berk c. Chimia (Aarau). 2019 May 29;73(5):368-373. doi: 10.2533/chimia.2019.368. Chimia (Aarau). 2019. PMID: 31118118 Free article. Review.

6

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6.

Garcia-Doval C, Schwede F, Berk C, Rostøl JT, Niewoehner O, Tejero O, Hall J, Marraffini LA, Jinek M. Garcia-Doval C, et al. Among authors: berk c. Nat Commun. 2020 Mar 27;11(1):1596. doi: 10.1038/s41467-020-15334-5. Nat Commun. 2020. PMID: 32221291 Free PMC article.

7

Pharmacodynamic and Pharmacokinetic Properties of Full Phosphorothioate Small Interfering RNAs for Gene Silencing In Vivo.

Berk C, Civenni G, Wang Y, Steuer C, Catapano CV, Hall J. Berk C, et al. Nucleic Acid Ther. 2021 Jun;31(3):237-244. doi: 10.1089/nat.2020.0852. Epub 2020 Apr 20. Nucleic Acid Ther. 2021. PMID: 32311310 Free PMC article.

8

Ligation of 2', 3'-cyclic phosphate RNAs for the identification of microRNA binding sites.

Berk C, Wang Y, Laski A, Tsagkris S, Hall J. Berk C, et al. FEBS Lett. 2021 Jan;595(2):230-240. doi: 10.1002/1873-3468.13976. Epub 2020 Nov 16. FEBS Lett. 2021. PMID: 33113149 Free PMC article.

9

Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease.

Lekka E, Kokanovic A, Mosole S, Civenni G, Schmidli S, Laski A, Ghidini A, Iyer P, Berk C, Behera A, Catapano CV, Hall J. Lekka E, et al. Among authors: berk c. Nat Commun. 2022 Dec 26;13(1):7940. doi: 10.1038/s41467-022-35481-1. Nat Commun. 2022. PMID: 36572670 Free PMC article.

10

Site-specific conjugation of drug-like fragments to an antimiR scaffold as a strategy to target miRNAs inside RISC.

Brunschweiger A, Gebert LF, Lucic M, Pradère U, Jahns H, Berk C, Hunziker J, Hall J. Brunschweiger A, et al. Among authors: berk c. Chem Commun (Camb). 2016 Jan 4;52(1):156-9. doi: 10.1039/c5cc07478a. Chem Commun (Camb). 2016. PMID: 26505838

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