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421 results

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Page 1
Discovery of a proneurogenic, neuroprotective chemical.
Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL. Pieper AA, et al. Among authors: williams ns. Cell. 2010 Jul 9;142(1):39-51. doi: 10.1016/j.cell.2010.06.018. Cell. 2010. PMID: 20603013 Free PMC article.
Development of proneurogenic, neuroprotective small molecules.
MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM. MacMillan KS, et al. Among authors: williams ns. J Am Chem Soc. 2011 Feb 9;133(5):1428-37. doi: 10.1021/ja108211m. Epub 2011 Jan 6. J Am Chem Soc. 2011. PMID: 21210688 Free PMC article.
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.
Tesla R, Wolf HP, Xu P, Drawbridge J, Estill SJ, Huntington P, McDaniel L, Knobbe W, Burket A, Tran S, Starwalt R, Morlock L, Naidoo J, Williams NS, Ready JM, McKnight SL, Pieper AA. Tesla R, et al. Among authors: williams ns. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17016-21. doi: 10.1073/pnas.1213960109. Epub 2012 Oct 1. Proc Natl Acad Sci U S A. 2012. PMID: 23027932 Free PMC article.
Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease.
De Jesús-Cortés H, Xu P, Drawbridge J, Estill SJ, Huntington P, Tran S, Britt J, Tesla R, Morlock L, Naidoo J, Melito LM, Wang G, Williams NS, Ready JM, McKnight SL, Pieper AA. De Jesús-Cortés H, et al. Among authors: williams ns. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17010-5. doi: 10.1073/pnas.1213956109. Epub 2012 Oct 1. Proc Natl Acad Sci U S A. 2012. PMID: 23027934 Free PMC article.
Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties.
Naidoo J, De Jesus-Cortes H, Huntington P, Estill S, Morlock LK, Starwalt R, Mangano TJ, Williams NS, Pieper AA, Ready JM. Naidoo J, et al. Among authors: williams ns. J Med Chem. 2014 May 8;57(9):3746-54. doi: 10.1021/jm401919s. Epub 2014 Apr 16. J Med Chem. 2014. PMID: 24697290 Free PMC article.
The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.
Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM. Walker AK, et al. Among authors: williams ns. Mol Psychiatry. 2015 Apr;20(4):500-8. doi: 10.1038/mp.2014.34. Epub 2014 Apr 22. Mol Psychiatry. 2015. PMID: 24751964 Free PMC article.
Pharmacologic rescue of motor and sensory function by the neuroprotective compound P7C3 following neonatal nerve injury.
Kemp SWP, Szynkaruk M, Stanoulis KN, Wood MD, Liu EH, Willand MP, Morlock L, Naidoo J, Williams NS, Ready JM, Mangano TJ, Beggs S, Salter MW, Gordon T, Pieper AA, Borschel GH. Kemp SWP, et al. Among authors: williams ns. Neuroscience. 2015 Jan 22;284:202-216. doi: 10.1016/j.neuroscience.2014.10.005. Epub 2014 Oct 13. Neuroscience. 2015. PMID: 25313000
Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243.
Dutca LM, Stasheff SF, Hedberg-Buenz A, Rudd DS, Batra N, Blodi FR, Yorek MS, Yin T, Shankar M, Herlein JA, Naidoo J, Morlock L, Williams N, Kardon RH, Anderson MG, Pieper AA, Harper MM. Dutca LM, et al. Invest Ophthalmol Vis Sci. 2014 Dec 2;55(12):8330-41. doi: 10.1167/iovs.14-15468. Invest Ophthalmol Vis Sci. 2014. PMID: 25468886 Free PMC article.
Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease.
De Jesús-Cortés H, Miller AD, Britt JK, DeMarco AJ, De Jesús-Cortés M, Stuebing E, Naidoo J, Vázquez-Rosa E, Morlock L, Williams NS, Ready JM, Narayanan NS, Pieper AA. De Jesús-Cortés H, et al. Among authors: williams ns. NPJ Parkinsons Dis. 2015;1:15010-. doi: 10.1038/npjparkd.2015.10. Epub 2015 May 21. NPJ Parkinsons Dis. 2015. PMID: 27158662 Free PMC article.
421 results