Ryu S - Search Results

1

Organic Anion-Transporting Polypeptide 1B1/1B3-Mediated Hepatic Uptake Determines the Pharmacokinetics of Large Lipophilic Acids: In Vitro-In Vivo Evaluation in Cynomolgus Monkey.

Eng H, Bi YA, West MA, Ryu S, Yamaguchi E, Kosa RE, Tess DA, Griffith DA, Litchfield J, Kalgutkar AS, Varma MVS. Eng H, et al. Among authors: ryu s. J Pharmacol Exp Ther. 2021 Apr;377(1):169-180. doi: 10.1124/jpet.120.000457. Epub 2021 Jan 28. J Pharmacol Exp Ther. 2021. PMID: 33509903

2

Novel Method to Predict In Vivo Liver-to-Plasma K_puu for OATP Substrates Using Suspension Hepatocytes.

Riccardi K, Lin J, Li Z, Niosi M, Ryu S, Hua W, Atkinson K, Kosa RE, Litchfield J, Di L. Riccardi K, et al. Among authors: ryu s. Drug Metab Dispos. 2017 May;45(5):576-580. doi: 10.1124/dmd.116.074575. Epub 2017 Mar 3. Drug Metab Dispos. 2017. PMID: 28258068

3

Discovery of Potent and Orally Bioavailable Macrocyclic Peptide-Peptoid Hybrid CXCR7 Modulators.

Boehm M, Beaumont K, Jones R, Kalgutkar AS, Zhang L, Atkinson K, Bai G, Brown JA, Eng H, Goetz GH, Holder BR, Khunte B, Lazzaro S, Limberakis C, Ryu S, Shapiro MJ, Tylaska L, Yan J, Turner R, Leung SSF, Ramaseshan M, Price DA, Liras S, Jacobson MP, Earp DJ, Lokey RS, Mathiowetz AM, Menhaji-Klotz E. Boehm M, et al. Among authors: ryu s. J Med Chem. 2017 Dec 14;60(23):9653-9663. doi: 10.1021/acs.jmedchem.7b01028. Epub 2017 Oct 30. J Med Chem. 2017. PMID: 29045152 Free article.

4

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects.

Li R, Niosi M, Johnson N, Tess DA, Kimoto E, Lin J, Yang X, Riccardi KA, Ryu S, El-Kattan AF, Maurer TS, Tremaine LM, Di L. Li R, et al. Among authors: ryu s. Drug Metab Dispos. 2018 Apr;46(4):346-356. doi: 10.1124/dmd.117.078790. Epub 2018 Jan 12. Drug Metab Dispos. 2018. PMID: 29330218

5

Comparison of Species and Cell-Type Differences in Fraction Unbound of Liver Tissues, Hepatocytes, and Cell Lines.

Riccardi K, Ryu S, Lin J, Yates P, Tess D, Li R, Singh D, Holder BR, Kapinos B, Chang G, Di L. Riccardi K, et al. Among authors: ryu s. Drug Metab Dispos. 2018 Apr;46(4):415-421. doi: 10.1124/dmd.117.079152. Epub 2018 Feb 2. Drug Metab Dispos. 2018. PMID: 29437874

6

6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol.

Lapham K, Lin J, Novak J, Orozco C, Niosi M, Di L, Goosen TC, Ryu S, Riccardi K, Eng H, Cameron KO, Kalgutkar AS. Lapham K, et al. Among authors: ryu s. Drug Metab Dispos. 2018 Dec;46(12):1836-1846. doi: 10.1124/dmd.118.083709. Epub 2018 Sep 7. Drug Metab Dispos. 2018. PMID: 30194276

7

A Novel Unified Approach to Predict Human Hepatic Clearance for Both Enzyme- and Transporter-Mediated Mechanisms Using Suspended Human Hepatocytes.

Riccardi KA, Tess DA, Lin J, Patel R, Ryu S, Atkinson K, Di L, Li R. Riccardi KA, et al. Among authors: ryu s. Drug Metab Dispos. 2019 May;47(5):484-492. doi: 10.1124/dmd.118.085639. Epub 2019 Feb 20. Drug Metab Dispos. 2019. PMID: 30787098

8

Evaluation of Fraction Unbound Across 7 Tissues of 5 Species.

Ryu S, Tess D, Chang G, Keefer C, Burchett W, Steeno GS, Novak JJ, Patel R, Atkinson K, Riccardi K, Di L. Ryu S, et al. J Pharm Sci. 2020 Feb;109(2):1178-1190. doi: 10.1016/j.xphs.2019.10.060. Epub 2019 Nov 5. J Pharm Sci. 2020. PMID: 31704191

9

Structural attributes influencing unbound tissue distribution.

Orozco CC, Atkinson K, Ryu S, Chang G, Keefer C, Lin J, Riccardi K, Mongillo RK, Tess D, Filipski KJ, Kalgutkar AS, Litchfield J, Scott D, Di L. Orozco CC, et al. Among authors: ryu s. Eur J Med Chem. 2020 Jan 1;185:111813. doi: 10.1016/j.ejmech.2019.111813. Epub 2019 Oct 28. Eur J Med Chem. 2020. PMID: 31732255

10

Comparison of Fraction Unbound Between Liver Homogenate and Hepatocytes at 4°C.

Riccardi K, Ryu S, Tess D, Li R, Luo L, Johnson N, Jordan S, Patel R, Di L. Riccardi K, et al. Among authors: ryu s. AAPS J. 2020 Jul 15;22(4):91. doi: 10.1208/s12248-020-00476-7. AAPS J. 2020. PMID: 32671577

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