Carles A - Search Results

1

Exposure of R6/2 mice in an enriched environment augments P42 therapy efficacy on Huntington's disease progression.

Couly S, Carles A, Denus M, Benigno-Anton L, Maschat F, Maurice T. Couly S, et al. Among authors: carles a. Neuropharmacology. 2021 Mar 15;186:108467. doi: 10.1016/j.neuropharm.2021.108467. Epub 2021 Jan 28. Neuropharmacology. 2021. PMID: 33516737

2

Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control of Inhibition in Vitro and Enable Restoration of Cognition in an Alzheimer's Disease Mouse Model upon Irradiation.

Scheiner M, Sink A, Hoffmann M, Vrigneau C, Endres E, Carles A, Sotriffer C, Maurice T, Decker M. Scheiner M, et al. Among authors: carles a. J Am Chem Soc. 2022 Feb 23;144(7):3279-3284. doi: 10.1021/jacs.1c13492. Epub 2022 Feb 9. J Am Chem Soc. 2022. PMID: 35138833

3

Heptafluoroisobutyronitrile (C₄F₇N), a gas used for insulating and arc quenching in electrical switchgear, is neurotoxic in the mouse brain.

Carles A, Schlernitzauer A, Vignes M, Cros G, Magous R, Maurice T, Oiry C. Carles A, et al. Toxicology. 2022 Oct;480:153319. doi: 10.1016/j.tox.2022.153319. Epub 2022 Sep 11. Toxicology. 2022. PMID: 36100137

4

Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model.

Spatz P, Steinmüller SAM, Tutov A, Poeta E, Morilleau A, Carles A, Deventer MH, Hofmann J, Stove CP, Monti B, Maurice T, Decker M. Spatz P, et al. Among authors: carles a. J Med Chem. 2023 May 11;66(9):6414-6435. doi: 10.1021/acs.jmedchem.3c00541. Epub 2023 Apr 26. J Med Chem. 2023. PMID: 37127287 Free PMC article.

5

Fluoroethylnormemantine (FENM) shows synergistic protection in combination with a sigma-1 receptor agonist in a mouse model of Alzheimer's disease.

Freyssin A, Carles A, Guehairia S, Rubinstenn G, Maurice T. Freyssin A, et al. Among authors: carles a. Neuropharmacology. 2024 Jan 1;242:109733. doi: 10.1016/j.neuropharm.2023.109733. Epub 2023 Oct 14. Neuropharmacology. 2024. PMID: 37844867

6

Convolamine, a tropane alkaloid extracted from Convolvulus plauricalis, is a potent sigma-1 receptor-positive modulator with cognitive and neuroprotective properties.

Crouzier L, Meunier J, Carles A, Morilleau A, Vrigneau C, Schmitt M, Bourguignon JJ, Delprat B, Maurice T. Crouzier L, et al. Among authors: carles a. Phytother Res. 2024 Feb;38(2):694-712. doi: 10.1002/ptr.8068. Epub 2023 Nov 27. Phytother Res. 2024. PMID: 38011416

7

Targeting N-Methyl-d-Aspartate Receptors in Neurodegenerative Diseases.

Carles A, Freyssin A, Perin-Dureau F, Rubinstenn G, Maurice T. Carles A, et al. Int J Mol Sci. 2024 Mar 27;25(7):3733. doi: 10.3390/ijms25073733. Int J Mol Sci. 2024. PMID: 38612544 Free PMC article. Review.

8

The selective butyrylcholinesterase inhibitor UW-MD-95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer's disease.

Carles A, Hoffmann M, Scheiner M, Crouzier L, Bertrand-Gaday C, Chatonnet A, Decker M, Maurice T. Carles A, et al. CNS Neurosci Ther. 2024 Jun;30(6):e14814. doi: 10.1111/cns.14814. CNS Neurosci Ther. 2024. PMID: 38887858 Free PMC article.

9

Long-Term Treatment with Fluoroethylnormemantine (FENM) Alleviated Memory Deficits, Amyloid Pathology, and Microglial Reaction in APP/PS1 Mice.

Freyssin A, Carles A, Moha B, Rubinstenn G, Maurice T. Freyssin A, et al. Among authors: carles a. ACS Pharmacol Transl Sci. 2024 Dec 2;7(12):4069-4082. doi: 10.1021/acsptsci.4c00522. eCollection 2024 Dec 13. ACS Pharmacol Transl Sci. 2024. PMID: 39698294

10

Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease.

Carles A, Freyssin A, Guehairia S, Reguero T, Vignes M, Hirbec H, Rubinstenn G, Maurice T. Carles A, et al. Alzheimers Res Ther. 2025 Jan 6;17(1):7. doi: 10.1186/s13195-024-01648-9. Alzheimers Res Ther. 2025. PMID: 39762936 Free PMC article.

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