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Self-delivering RNAi compounds as therapeutic agents in the central nervous system to enhance axonal regeneration after injury.
Woller SA, Ruschel J, Morquette B, Cardia J, Yan D, Holton K, Shmushkovich T, Niederst E, Bulock K, Wolfson A, Abbinanti M, Fournier AE, McKerracher L, Rosen KM. Woller SA, et al. Among authors: ruschel j. iScience. 2022 May 10;25(6):104379. doi: 10.1016/j.isci.2022.104379. eCollection 2022 Jun 17. iScience. 2022. PMID: 35620420 Free PMC article.
Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models.
Liu Y, Dodart JC, Tran H, Berkovitch S, Braun M, Byrne M, Durbin AF, Hu XS, Iwamoto N, Jang HG, Kandasamy P, Liu F, Longo K, Ruschel J, Shelke J, Yang H, Yin Y, Donner A, Zhong Z, Vargeese C, Brown RH Jr. Liu Y, et al. Among authors: ruschel j. Nat Commun. 2021 Feb 8;12(1):847. doi: 10.1038/s41467-021-21112-8. Nat Commun. 2021. PMID: 33558503 Free PMC article.
A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
McKerracher L, Shenkar R, Abbinanti M, Cao Y, Peiper A, Liao JK, Lightle R, Moore T, Hobson N, Gallione C, Ruschel J, Koskimäki J, Girard R, Rosen K, Marchuk DA, Awad IA. McKerracher L, et al. Among authors: ruschel j. Transl Stroke Res. 2020 Jun;11(3):365-376. doi: 10.1007/s12975-019-00725-8. Epub 2019 Aug 24. Transl Stroke Res. 2020. PMID: 31446620 Free PMC article.
Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury.
Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C, Brook G, Dobrindt K, Peitz M, Brüstle O, Norenberg MD, Blesch A, Weidner N, Bunge MB, Bixby JL, Bradke F. Ruschel J, et al. Science. 2015 Apr 17;348(6232):347-52. doi: 10.1126/science.aaa2958. Epub 2015 Mar 12. Science. 2015. PMID: 25765066 Free PMC article.
11 results