Lynch KD - Search Results

1

Hepatic organic anion transporting polypeptides mediate disposition of milk thistle flavonolignans and pharmacokinetic silymarin-drug interactions.

Lynch KD, Montonye ML, Tian DD, Arman T, Oyanna VO, Bechtold BJ, Graf TN, Oberlies NH, Paine MF, Clarke JD. Lynch KD, et al. Phytother Res. 2021 Jun;35(6):3286-3297. doi: 10.1002/ptr.7049. Epub 2021 Feb 15. Phytother Res. 2021. PMID: 33587330 Free PMC article.

2

Nonalcoholic fatty liver disease alters microcystin-LR toxicokinetics and acute toxicity.

Clarke JD, Dzierlenga A, Arman T, Toth E, Li H, Lynch KD, Tian DD, Goedken M, Paine MF, Cherrington N. Clarke JD, et al. Among authors: lynch kd. Toxicon. 2019 Apr 15;162:1-8. doi: 10.1016/j.toxicon.2019.03.002. Epub 2019 Mar 5. Toxicon. 2019. PMID: 30849452 Free PMC article.

3

Sub-Chronic Microcystin-LR Liver Toxicity in Preexisting Diet-Induced Nonalcoholic Steatohepatitis in Rats.

Arman T, Lynch KD, Montonye ML, Goedken M, Clarke JD. Arman T, et al. Among authors: lynch kd. Toxins (Basel). 2019 Jul 9;11(7):398. doi: 10.3390/toxins11070398. Toxins (Basel). 2019. PMID: 31323923 Free PMC article.

4

A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcoholic Steatohepatitis on Hepatic Transporters in a Rat Model.

Montonye ML, Tian DD, Arman T, Lynch KD, Hagenbuch B, Paine MF, Clarke JD. Montonye ML, et al. Among authors: lynch kd. J Pharmacol Exp Ther. 2019 Nov;371(2):385-393. doi: 10.1124/jpet.119.260489. Epub 2019 Aug 16. J Pharmacol Exp Ther. 2019. PMID: 31420525 Free PMC article.

5

Sub-chronic microcystin-LR renal toxicity in rats fed a high fat/high cholesterol diet.

Arman T, Lynch KD, Goedken M, Clarke JD. Arman T, et al. Among authors: lynch kd. Chemosphere. 2021 Apr;269:128773. doi: 10.1016/j.chemosphere.2020.128773. Epub 2020 Oct 27. Chemosphere. 2021. PMID: 33143886 Free PMC article.

6

MCLR-elicited hepatic fibrosis and carcinogenic gene expression changes persist in rats with diet-induced nonalcoholic steatohepatitis through a 4-week recovery period.

Arman T, Baron JA, Lynch KD, White LA, Aldan J, Clarke JD. Arman T, et al. Among authors: lynch kd. Toxicology. 2021 Dec;464:153021. doi: 10.1016/j.tox.2021.153021. Epub 2021 Nov 2. Toxicology. 2021. PMID: 34740672 Free PMC article.

7

Involvement of the p38/MK2 Pathway in MCLR Hepatotoxicity Revealed through MAPK Pharmacological Inhibition and Phosphoproteomics in HepaRG Cells.

Lynch KD, Iverson DT, Bachhav NK, Call MR, Yue GE, Prasad B, Clarke JD. Lynch KD, et al. Int J Mol Sci. 2023 Jul 6;24(13):11168. doi: 10.3390/ijms241311168. Int J Mol Sci. 2023. PMID: 37446360 Free PMC article.

8

Goldenseal-Mediated Inhibition of Intestinal Uptake Transporters Decreases Metformin Systemic Exposure in Mice.

Oyanna VO, Garcia-Torres KY, Bechtold BJ, Lynch KD, Call MR, Horváth M, Manwill PK, Graf TN, Cech NB, Oberlies NH, Paine MF, Clarke JD. Oyanna VO, et al. Among authors: lynch kd. Drug Metab Dispos. 2023 Nov;51(11):1483-1489. doi: 10.1124/dmd.123.001360. Epub 2023 Aug 10. Drug Metab Dispos. 2023. PMID: 37562957 Free PMC article.

9

Green Tea Catechins Decrease Solubility of Raloxifene In Vitro and Its Systemic Exposure in Mice.

Oyanna VO, Bechtold BJ, Lynch KD, Ridge Call M, Graf TN, Oberlies NH, Clarke JD. Oyanna VO, et al. Among authors: lynch kd. Pharm Res. 2024 Mar;41(3):557-566. doi: 10.1007/s11095-024-03662-w. Epub 2024 Feb 1. Pharm Res. 2024. PMID: 38302834

10

Pharmacokinetic Effects of Different Models of Nonalcoholic Fatty Liver Disease in Transgenic Humanized OATP1B Mice.

Bechtold BJ, Lynch KD, Oyanna VO, Call MR, White LA, Graf TN, Oberlies NH, Clarke JD. Bechtold BJ, et al. Among authors: lynch kd. Drug Metab Dispos. 2024 Apr 16;52(5):355-367. doi: 10.1124/dmd.123.001607. Drug Metab Dispos. 2024. PMID: 38485280 Free PMC article.

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