Aittokallio T - Search Results

1

Patient-tailored design for selective co-inhibition of leukemic cell subpopulations.

Ianevski A, Lahtela J, Javarappa KK, Sergeev P, Ghimire BR, Gautam P, Vähä-Koskela M, Turunen L, Linnavirta N, Kuusanmäki H, Kontro M, Porkka K, Heckman CA, Mattila P, Wennerberg K, Giri AK, Aittokallio T. Ianevski A, et al. Among authors: aittokallio t. Sci Adv. 2021 Feb 19;7(8):eabe4038. doi: 10.1126/sciadv.abe4038. Print 2021 Feb. Sci Adv. 2021. PMID: 33608276 Free PMC article.

2

Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia.

Pemovska T, Kontro M, Yadav B, Edgren H, Eldfors S, Szwajda A, Almusa H, Bespalov MM, Ellonen P, Elonen E, Gjertsen BT, Karjalainen R, Kulesskiy E, Lagström S, Lehto A, Lepistö M, Lundán T, Majumder MM, Marti JM, Mattila P, Murumägi A, Mustjoki S, Palva A, Parsons A, Pirttinen T, Rämet ME, Suvela M, Turunen L, Västrik I, Wolf M, Knowles J, Aittokallio T, Heckman CA, Porkka K, Kallioniemi O, Wennerberg K. Pemovska T, et al. Among authors: aittokallio t. Cancer Discov. 2013 Dec;3(12):1416-29. doi: 10.1158/2159-8290.CD-13-0350. Epub 2013 Sep 20. Cancer Discov. 2013. PMID: 24056683

3

Target inhibition networks: predicting selective combinations of druggable targets to block cancer survival pathways.

Tang J, Karhinen L, Xu T, Szwajda A, Yadav B, Wennerberg K, Aittokallio T. Tang J, et al. Among authors: aittokallio t. PLoS Comput Biol. 2013;9(9):e1003226. doi: 10.1371/journal.pcbi.1003226. Epub 2013 Sep 12. PLoS Comput Biol. 2013. PMID: 24068907 Free PMC article.

4

Making sense of large-scale kinase inhibitor bioactivity data sets: a comparative and integrative analysis.

Tang J, Szwajda A, Shakyawar S, Xu T, Hintsanen P, Wennerberg K, Aittokallio T. Tang J, et al. Among authors: aittokallio t. J Chem Inf Model. 2014 Mar 24;54(3):735-43. doi: 10.1021/ci400709d. Epub 2014 Feb 21. J Chem Inf Model. 2014. PMID: 24521231

5

Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies.

Yadav B, Pemovska T, Szwajda A, Kulesskiy E, Kontro M, Karjalainen R, Majumder MM, Malani D, Murumägi A, Knowles J, Porkka K, Heckman C, Kallioniemi O, Wennerberg K, Aittokallio T. Yadav B, et al. Among authors: aittokallio t. Sci Rep. 2014 Jun 5;4:5193. doi: 10.1038/srep05193. Sci Rep. 2014. PMID: 24898935 Free PMC article.

6

Statistical detection of quantitative protein biomarkers provides insights into signaling networks deregulated in acute myeloid leukemia.

Elo LL, Karjalainen R, Ohman T, Hintsanen P, Nyman TA, Heckman CA, Aittokallio T. Elo LL, et al. Among authors: aittokallio t. Proteomics. 2014 Nov;14(21-22):2443-53. doi: 10.1002/pmic.201300460. Epub 2014 Oct 15. Proteomics. 2014. PMID: 25211154

7

TIMMA-R: an R package for predicting synergistic multi-targeted drug combinations in cancer cell lines or patient-derived samples.

He L, Wennerberg K, Aittokallio T, Tang J. He L, et al. Among authors: aittokallio t. Bioinformatics. 2015 Jun 1;31(11):1866-8. doi: 10.1093/bioinformatics/btv067. Epub 2015 Jan 31. Bioinformatics. 2015. PMID: 25638808 Free PMC article.

8

Network pharmacology applications to map the unexplored target space and therapeutic potential of natural products.

Kibble M, Saarinen N, Tang J, Wennerberg K, Mäkelä S, Aittokallio T. Kibble M, et al. Among authors: aittokallio t. Nat Prod Rep. 2015 Aug;32(8):1249-66. doi: 10.1039/c5np00005j. Nat Prod Rep. 2015. PMID: 26030402 Review.

9

Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles.

Szwajda A, Gautam P, Karhinen L, Jha SK, Saarela J, Shakyawar S, Turunen L, Yadav B, Tang J, Wennerberg K, Aittokallio T. Szwajda A, et al. Among authors: aittokallio t. Chem Biol. 2015 Aug 20;22(8):1144-55. doi: 10.1016/j.chembiol.2015.06.021. Epub 2015 Jul 23. Chem Biol. 2015. PMID: 26211361

10

Impact of normalization methods on high-throughput screening data with high hit rates and drug testing with dose-response data.

Mpindi JP, Swapnil P, Dmitrii B, Jani S, Saeed K, Wennerberg K, Aittokallio T, Östling P, Kallioniemi O. Mpindi JP, et al. Among authors: aittokallio t. Bioinformatics. 2015 Dec 1;31(23):3815-21. doi: 10.1093/bioinformatics/btv455. Epub 2015 Aug 7. Bioinformatics. 2015. PMID: 26254433 Free PMC article.

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