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Amphiregulin-producing γδ T cells are vital for safeguarding oral barrier immune homeostasis.
Krishnan S, Prise IE, Wemyss K, Schenck LP, Bridgeman HM, McClure FA, Zangerle-Murray T, O'Boyle C, Barbera TA, Mahmood F, Bowdish DME, Zaiss DMW, Grainger JR, Konkel JE. Krishnan S, et al. Among authors: bridgeman hm. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10738-10743. doi: 10.1073/pnas.1802320115. Epub 2018 Oct 2. Proc Natl Acad Sci U S A. 2018. PMID: 30279177 Free PMC article.
On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier.
Dutzan N, Abusleme L, Bridgeman H, Greenwell-Wild T, Zangerle-Murray T, Fife ME, Bouladoux N, Linley H, Brenchley L, Wemyss K, Calderon G, Hong BY, Break TJ, Bowdish DME, Lionakis MS, Jones SA, Trinchieri G, Diaz PI, Belkaid Y, Konkel JE, Moutsopoulos NM. Dutzan N, et al. Immunity. 2017 Jan 17;46(1):133-147. doi: 10.1016/j.immuni.2016.12.010. Epub 2017 Jan 10. Immunity. 2017. PMID: 28087239 Free PMC article.
Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.
Colbeck EJ, Hindley JP, Smart K, Jones E, Bloom A, Bridgeman H, McPherson RC, Turner DG, Ladell K, Price DA, O'Connor RA, Anderton SM, Godkin AJ, Gallimore AM. Colbeck EJ, et al. Oncotarget. 2015 Sep 22;6(28):24649-59. doi: 10.18632/oncotarget.5584. Oncotarget. 2015. PMID: 26433463 Free PMC article.
Avidity of influenza-specific memory CD8+ T-cell populations decays over time compromising antiviral immunity.
Humphreys IR, Clement M, Marsden M, Ladell K, McLaren JE, Smart K, Hindley JP, Bridgeman HM, van den Berg HA, Price DA, Ager A, Wooldridge L, Godkin A, Gallimore AM. Humphreys IR, et al. Among authors: bridgeman hm. Eur J Immunol. 2012 Dec;42(12):3235-42. doi: 10.1002/eji.201242575. Epub 2012 Oct 16. Eur J Immunol. 2012. PMID: 22965681 Free PMC article.
Escalating regulation of 5T4-specific IFN-γ+ CD4+ T cells distinguishes colorectal cancer patients from healthy controls and provides a target for in vivo therapy.
Scurr M, Bloom A, Pembroke T, Srinivasan R, Brown C, Smart K, Bridgeman H, Davies M, Hargest R, Phillips S, Christian A, Hockey T, Gallimore A, Godkin A. Scurr M, et al. Cancer Immunol Res. 2013 Dec;1(6):10.1158/2326-6066.CIR-13-0035. doi: 10.1158/2326-6066.CIR-13-0035. Cancer Immunol Res. 2013. PMID: 24409450 Free PMC article.
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