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The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model.
Jeffers JR, Pinto EM, Rehg JE, Clay MR, Wang J, Neale G, Heath RJ, Lozano G, Lalli E, Figueiredo BC, Pappo AS, Rodriguez-Galindo C, Chen W, Pounds S, Ribeiro RC, Zambetti GP. Jeffers JR, et al. Among authors: heath rj. Cancer Res. 2021 May 1;81(9):2442-2456. doi: 10.1158/0008-5472.CAN-20-1750. Epub 2021 Feb 26. Cancer Res. 2021. PMID: 33637564 Free PMC article.
Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication.
Punchihewa C, Inoue A, Hishiki A, Fujikawa Y, Connelly M, Evison B, Shao Y, Heath R, Kuraoka I, Rodrigues P, Hashimoto H, Kawanishi M, Sato M, Yagi T, Fujii N. Punchihewa C, et al. J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1. J Biol Chem. 2012. PMID: 22383522 Free PMC article.
A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.
Inoue A, Kikuchi S, Hishiki A, Shao Y, Heath R, Evison BJ, Actis M, Canman CE, Hashimoto H, Fujii N. Inoue A, et al. J Biol Chem. 2014 Mar 7;289(10):7109-7120. doi: 10.1074/jbc.M113.520429. Epub 2014 Jan 28. J Biol Chem. 2014. PMID: 24474685 Free PMC article.
63 results