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Patterns of neuronal Rhes as a novel hallmark of tauopathies.
Ehrenberg AJ, Leng K, Letourneau KN, Hernandez I, Lew C, Seeley WW, Spina S, Miller B, Heinsen H, Kampmann M, Kosik KS, Grinberg LT. Ehrenberg AJ, et al. Among authors: kosik ks. Acta Neuropathol. 2021 May;141(5):651-666. doi: 10.1007/s00401-021-02279-2. Epub 2021 Mar 7. Acta Neuropathol. 2021. PMID: 33677647 Free PMC article.
Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.
Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MHU, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, Steen JA, Haggarty SJ. Silva MC, et al. Among authors: kosik ks. Stem Cell Reports. 2016 Sep 13;7(3):325-340. doi: 10.1016/j.stemcr.2016.08.001. Epub 2016 Sep 1. Stem Cell Reports. 2016. PMID: 27594585 Free PMC article.
RNA stores tau reversibly in complex coacervates.
Zhang X, Lin Y, Eschmann NA, Zhou H, Rauch JN, Hernandez I, Guzman E, Kosik KS, Han S. Zhang X, et al. Among authors: kosik ks. PLoS Biol. 2017 Jul 6;15(7):e2002183. doi: 10.1371/journal.pbio.2002183. eCollection 2017 Jul. PLoS Biol. 2017. PMID: 28683104 Free PMC article.
A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.
Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate AM, Fisher SK, Cuervo AM, Kosik KS. Hernandez I, et al. Among authors: kosik ks. Sci Transl Med. 2019 Mar 27;11(485):eaat3005. doi: 10.1126/scitranslmed.aat3005. Sci Transl Med. 2019. PMID: 30918111 Free PMC article.
342 results