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Page 1
Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis.
Brebion F, Gosmini R, Deprez P, Varin M, Peixoto C, Alvey L, Jary H, Bienvenu N, Triballeau N, Blanque R, Cottereaux C, Christophe T, Vandervoort N, Mollat P, Touitou R, Leonard P, De Ceuninck F, Botez I, Monjardet A, van der Aar E, Amantini D. Brebion F, et al. Among authors: de ceuninck f. J Med Chem. 2021 Mar 25;64(6):2937-2952. doi: 10.1021/acs.jmedchem.0c02008. Epub 2021 Mar 15. J Med Chem. 2021. PMID: 33719441 Free article.
Access to Galectin-3 Inhibitors from Chemoenzymatic Synthons.
Dussouy C, Téletchéa S, Lambert A, Charlier C, Botez I, De Ceuninck F, Grandjean C. Dussouy C, et al. Among authors: de ceuninck f. J Org Chem. 2020 Dec 18;85(24):16099-16114. doi: 10.1021/acs.joc.0c01927. Epub 2020 Nov 17. J Org Chem. 2020. PMID: 33200927
Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5.
Clement-Lacroix P, Little CB, Smith MM, Cottereaux C, Merciris D, Meurisse S, Mollat P, Touitou R, Brebion F, Gosmini R, De Ceuninck F, Botez I, Lepescheux L, van der Aar E, Christophe T, Vandervoort N, Blanqué R, Comas D, Deprez P, Amantini D. Clement-Lacroix P, et al. Among authors: de ceuninck f. Osteoarthritis Cartilage. 2022 Feb;30(2):291-301. doi: 10.1016/j.joca.2021.08.012. Epub 2021 Oct 6. Osteoarthritis Cartilage. 2022. PMID: 34626798 Free article.
Design, synthesis and biological evaluation of conformationnally-restricted analogues of E7010 as inhibitors of tubulin assembly (ITA) and vascular disrupting agents (VDA).
Prudhomme V, Cucca M, Nauton L, Andrieu E, Fereyrolles M, Lamoine S, Michelin C, Bennis K, Collin A, De Ceuninck F, Botez I, Mallet C, Ducki S. Prudhomme V, et al. Among authors: de ceuninck f. Eur J Med Chem. 2022 Dec 15;244:114809. doi: 10.1016/j.ejmech.2022.114809. Epub 2022 Oct 1. Eur J Med Chem. 2022. PMID: 36208509
Targeting galectin-3 in inflammatory and fibrotic diseases.
Bouffette S, Botez I, De Ceuninck F. Bouffette S, et al. Among authors: de ceuninck f. Trends Pharmacol Sci. 2023 Aug;44(8):519-531. doi: 10.1016/j.tips.2023.06.001. Epub 2023 Jun 28. Trends Pharmacol Sci. 2023. PMID: 37391294 Free article. Review.
Structure-Activity Relationship of Azaindole-Based Glucokinase Activators.
Paczal A, Bálint B, Wéber C, Szabó ZB, Ondi L, Theret I, De Ceuninck F, Bernard C, Ktorza A, Perron-Sierra F, Kotschy A. Paczal A, et al. Among authors: de ceuninck f. J Med Chem. 2016 Jan 28;59(2):687-706. doi: 10.1021/acs.jmedchem.5b01594. Epub 2016 Jan 15. J Med Chem. 2016. PMID: 26685731
Proteomics: addressing the challenges of osteoarthritis.
De Ceuninck F, Berenbaum F. De Ceuninck F, et al. Drug Discov Today. 2009 Jul;14(13-14):661-7. doi: 10.1016/j.drudis.2009.05.006. Epub 2009 May 27. Drug Discov Today. 2009. PMID: 19477289 Review.
44 results