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Older Adults Demonstrate Biomarker Evidence of the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS) After Sepsis.
Mankowski RT, Anton SD, Ghita GL, Brumback B, Darden DB, Bihorac A, Leeuwenburgh C, Moldawer LL, Efron PA, Brakenridge SC, Moore FA. Mankowski RT, et al. Among authors: darden db. J Gerontol A Biol Sci Med Sci. 2022 Jan 7;77(1):188-196. doi: 10.1093/gerona/glab080. J Gerontol A Biol Sci Med Sci. 2022. PMID: 33721883 Free PMC article.
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.
Hollen MK, Stortz JA, Darden D, Dirain ML, Nacionales DC, Hawkins RB, Cox MC, Lopez MC, Rincon JC, Ungaro R, Wang Z, Wu Q, Brumback B, Gauthier ML, Kladde M, Leeuwenburgh C, Segal M, Bihorac A, Brakenridge S, Moore FA, Baker HV, Mohr AM, Moldawer LL, Efron PA. Hollen MK, et al. Crit Care. 2019 Nov 13;23(1):355. doi: 10.1186/s13054-019-2628-x. Crit Care. 2019. PMID: 31722736 Free PMC article.
Identification of Unique mRNA and miRNA Expression Patterns in Bone Marrow Hematopoietic Stem and Progenitor Cells After Trauma in Older Adults.
Darden DB, Stortz JA, Hollen MK, Cox MC, Apple CG, Hawkins RB, Rincon JC, Lopez MC, Wang Z, Navarro E, Hagen JE, Parvataneni HK, Brusko MA, Kladde M, Bacher R, Brumback BA, Brakenridge SC, Baker HV, Cogle CR, Mohr AM, Efron PA. Darden DB, et al. Front Immunol. 2020 Jun 24;11:1289. doi: 10.3389/fimmu.2020.01289. eCollection 2020. Front Immunol. 2020. PMID: 32670283 Free PMC article.
Septic Stability? Gut Microbiota in Young Adult Mice Maintains Overall Stability After Sepsis Compared to Old Adult Mice.
Mankowski RT, Thomas RM, Darden DB, Gharaibeh RZ, Hawkins RB, Cox MC, Apple C, Nacionales DC, Ungaro RF, Dirain ML, Moore FA, Leeuwenburgh C, Brakenridge SC, Clanton TL, Laitano O, Moldawer LL, Mohr AM, Efron PA. Mankowski RT, et al. Among authors: darden db. Shock. 2021 Apr 1;55(4):519-525. doi: 10.1097/SHK.0000000000001648. Shock. 2021. PMID: 32826817 Free PMC article.
Single-Cell RNA-seq of Human Myeloid-Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets With Unique Transcriptional Responses: A Pilot Study.
Darden DB, Bacher R, Brusko MA, Knight P, Hawkins RB, Cox MC, Dirain ML, Ungaro R, Nacionales DC, Rincon JC, Gauthier ML, Kladde M, Bihorac A, Brusko TM, Moore FA, Brakenridge SC, Mohr AM, Moldawer LL, Efron PA. Darden DB, et al. Shock. 2021 May 1;55(5):587-595. doi: 10.1097/SHK.0000000000001671. Shock. 2021. PMID: 33021571 Free PMC article.
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis.
Efron PA, Darden DB, Wang Z, Nacionales DC, Lopez MC, Hawkins RB, Cox MC, Rincon JC, Ungaro R, Dirain ML, Ghita GL, Chen T, Billiar TR, Delano MJ, Leeuwenburgh C, Bihorac A, Brakenridge SC, Moore FA, Mohr AM, Tompkins RG, Brumback BA, Baker HV, Upchurch GR, Moldawer LL. Efron PA, et al. Among authors: darden db. FASEB J. 2021 Feb;35(2):e21156. doi: 10.1096/fj.202002150R. Epub 2020 Nov 2. FASEB J. 2021. PMID: 33140449 Free PMC article.
The Effect of Aging Physiology on Critical Care.
Darden DB, Moore FA, Brakenridge SC, Navarro EB, Anton SD, Leeuwenburgh C, Moldawer LL, Mohr AM, Efron PA, Mankowski RT. Darden DB, et al. Crit Care Clin. 2021 Jan;37(1):135-150. doi: 10.1016/j.ccc.2020.08.006. Epub 2020 Oct 28. Crit Care Clin. 2021. PMID: 33190766 Free PMC article. Review.
32 results