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Adolescent self-administration of the synthetic cannabinoid receptor agonist JWH-018 induces neurobiological and behavioral alterations in adult male mice.
Margiani G, Castelli MP, Pintori N, Frau R, Ennas MG, Pagano Zottola AC, Orrù V, Serra V, Fiorillo E, Fadda P, Marsicano G, De Luca MA. Margiani G, et al. Among authors: pintori n. Psychopharmacology (Berl). 2022 Oct;239(10):3083-3102. doi: 10.1007/s00213-022-06191-9. Epub 2022 Aug 9. Psychopharmacology (Berl). 2022. PMID: 35943523 Free PMC article.
Repeated exposure to JWH-018 induces adaptive changes in the mesolimbic and mesocortical dopaminergic pathways, glial cells alterations, and behavioural correlates.
Pintori N, Castelli MP, Miliano C, Simola N, Fadda P, Fattore L, Scherma M, Ennas MG, Mostallino R, Flore G, De Felice M, Sagheddu C, Pistis M, Di Chiara G, De Luca MA. Pintori N, et al. Br J Pharmacol. 2021 Sep;178(17):3476-3497. doi: 10.1111/bph.15494. Epub 2021 Jun 29. Br J Pharmacol. 2021. PMID: 33837969 Free PMC article.
34 results