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Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy.
Tavora B, Reynolds LE, Batista S, Demircioglu F, Fernandez I, Lechertier T, Lees DM, Wong PP, Alexopoulou A, Elia G, Clear A, Ledoux A, Hunter J, Perkins N, Gribben JG, Hodivala-Dilke KM. Tavora B, et al. Among authors: lees dm. Nature. 2014 Oct 2;514(7520):112-6. doi: 10.1038/nature13541. Epub 2014 Jul 27. Nature. 2014. PMID: 25079333 Free PMC article.
Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861.
Pedrosa AR, Bodrug N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T, Hodivala-Dilke KM. Pedrosa AR, et al. Among authors: lees dm. Cancer Res. 2019 Sep 1;79(17):4371-4386. doi: 10.1158/0008-5472.CAN-18-3934. Epub 2019 Jun 12. Cancer Res. 2019. PMID: 31189647
Generation of point-mutant FAK knockin mice.
Tavora B, Batista S, Alexopoulou AN, Kostourou V, Fernandez I, Robinson SD, Lees DM, Serrels B, Hodivala-Dilke K. Tavora B, et al. Among authors: lees dm. Genesis. 2014 Nov;52(11):907-15. doi: 10.1002/dvg.22823. Epub 2014 Sep 30. Genesis. 2014. PMID: 25242698
FAK-heterozygous mice display enhanced tumour angiogenesis.
Kostourou V, Lechertier T, Reynolds LE, Lees DM, Baker M, Jones DT, Tavora B, Ramjaun AR, Birdsey GM, Robinson SD, Parsons M, Randi AM, Hart IR, Hodivala-Dilke K. Kostourou V, et al. Among authors: lees dm. Nat Commun. 2013;4:2020. doi: 10.1038/ncomms3020. Nat Commun. 2013. PMID: 23799510 Free PMC article.
39 results