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Impaired Very-Low-Density Lipoprotein catabolism links hypoglycemia to hypertriglyceridemia in Glycogen Storage Disease type Ia.
Hoogerland JA, Peeks F, Hijmans BS, Wolters JC, Kooijman S, Bos T, Bleeker A, van Dijk TH, Wolters H, Gerding A, van Eunen K, Havinga R, Pronk ACM, Rensen PCN, Mithieux G, Rajas F, Kuipers F, Reijngoud DJ, Derks TGJ, Oosterveer MH. Hoogerland JA, et al. Among authors: mithieux g. J Inherit Metab Dis. 2021 Jul;44(4):879-892. doi: 10.1002/jimd.12380. Epub 2021 Apr 7. J Inherit Metab Dis. 2021. PMID: 33739445 Free PMC article.
Phosphatidylinositol 3-kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding.
Daniele N, Rajas F, Payrastre B, Mauco G, Zitoun C, Mithieux G. Daniele N, et al. Among authors: mithieux g. J Biol Chem. 1999 Feb 5;274(6):3597-601. doi: 10.1074/jbc.274.6.3597. J Biol Chem. 1999. PMID: 9920907 Free article.
This process, via the lipid products of PI3K, which are potent inhibitors of glucose-6-phosphatase (Mithieux, G., Daniele, N., Payrastre, B., and Zitoun, C. (1998) J. Biol. Chem. 273, 17-19), may account for the inhibition of the enzyme and participate to the inhibi …
This process, via the lipid products of PI3K, which are potent inhibitors of glucose-6-phosphatase (Mithieux, G., Daniele, N., …
181 results