Henke BR - Search Results

1

A novel small molecule approach for the treatment of propionic and methylmalonic acidemias.

Armstrong AJ, Collado MS, Henke BR, Olson MW, Hoang SA, Hamilton CA, Pourtaheri TD, Chapman KA, Summar MM, Johns BA, Wamhoff BR, Reardon JE, Figler RA. Armstrong AJ, et al. Among authors: henke br. Mol Genet Metab. 2021 May;133(1):71-82. doi: 10.1016/j.ymgme.2021.03.001. Epub 2021 Mar 10. Mol Genet Metab. 2021. PMID: 33741272 Free PMC article.

2

Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia.

Armstrong AJ, Henke BR, Collado MS, Taylor JM, Pourtaheri TD, Dillberger JE, Roper TD, Wamhoff BR, Olson MW, Figler RA, Hoang SA, Reardon JE, Johns BA. Armstrong AJ, et al. Among authors: henke br. J Med Chem. 2021 Apr 22;64(8):5037-5048. doi: 10.1021/acs.jmedchem.1c00124. Epub 2021 Apr 13. J Med Chem. 2021. PMID: 33848153 Free article.

3

Elimination of a cholecystokinin receptor agonist 'trigger' in an effort to develop positive allosteric modulators without intrinsic agonist activity.

Desai AJ, Henke BR, Miller LJ. Desai AJ, et al. Among authors: henke br. Bioorg Med Chem Lett. 2015 May 1;25(9):1849-55. doi: 10.1016/j.bmcl.2015.03.051. Epub 2015 Mar 24. Bioorg Med Chem Lett. 2015. PMID: 25862198 Free PMC article.

4

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors.

Haffner CD, Becherer JD, Boros EE, Cadilla R, Carpenter T, Cowan D, Deaton DN, Guo Y, Harrington W, Henke BR, Jeune MR, Kaldor I, Milliken N, Petrov KG, Preugschat F, Schulte C, Shearer BG, Shearer T, Smalley TL Jr, Stewart EL, Stuart JD, Ulrich JC. Haffner CD, et al. Among authors: henke br. J Med Chem. 2015 Apr 23;58(8):3548-71. doi: 10.1021/jm502009h. Epub 2015 Apr 10. J Med Chem. 2015. PMID: 25828863

5

Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.

Henke BR, Adkison KK, Blanchard SG, Leesnitzer LM, Mook RA Jr, Plunket KD, Ray JA, Roberson C, Unwalla R, Willson TM. Henke BR, et al. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3329-34. doi: 10.1016/s0960-894x(99)00603-4. Bioorg Med Chem Lett. 1999. PMID: 10612594

6

2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships.

Deaton DN, Haffner CD, Henke BR, Jeune MR, Shearer BG, Stewart EL, Stuart JD, Ulrich JC. Deaton DN, et al. Among authors: henke br. Bioorg Med Chem. 2018 May 1;26(8):2107-2150. doi: 10.1016/j.bmc.2018.03.021. Epub 2018 Mar 15. Bioorg Med Chem. 2018. PMID: 29576271

7

Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes.

Henke BR. Henke BR. J Med Chem. 2004 Aug 12;47(17):4118-27. doi: 10.1021/jm030631e. J Med Chem. 2004. PMID: 15293980 Review. No abstract available.

8

A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta.

Henke BR, Consler TG, Go N, Hale RL, Hohman DR, Jones SA, Lu AT, Moore LB, Moore JT, Orband-Miller LA, Robinett RG, Shearin J, Spearing PK, Stewart EL, Turnbull PS, Weaver SL, Williams SP, Wisely GB, Lambert MH. Henke BR, et al. J Med Chem. 2002 Dec 5;45(25):5492-505. doi: 10.1021/jm020291h. J Med Chem. 2002. PMID: 12459017

9

Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor.

Harikumar KG, Cawston EE, Lam PCH, Patil A, Orry A, Henke BR, Abagyan R, Christopoulos A, Sexton PM, Miller LJ. Harikumar KG, et al. Among authors: henke br. J Biol Chem. 2013 Jul 19;288(29):21082-21095. doi: 10.1074/jbc.M113.480715. Epub 2013 Jun 10. J Biol Chem. 2013. PMID: 23754289 Free PMC article.

10

3-(1H-indazol-3-ylmethyl)-1,5-benzodiazepines: CCK-A agonists that demonstrate oral activity as satiety agents.

Henke BR, Willson TM, Sugg EE, Croom DK, Dougherty RW Jr, Queen KL, Birkemo LS, Ervin GN, Grizzle MK, Johnson MF, James MK. Henke BR, et al. J Med Chem. 1996 Jul 5;39(14):2655-8. doi: 10.1021/jm960249k. J Med Chem. 1996. PMID: 8709093 No abstract available.

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