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The rare C9 P167S risk variant for age-related macular degeneration increases polymerization of the terminal component of the complement cascade.
McMahon O, Hallam TM, Patel S, Harris CL, Menny A, Zelek WM, Widjajahakim R, Java A, Cox TE, Tzoumas N, Steel DHW, Shuttleworth VG, Smith-Jackson K, Brocklebank V, Griffiths H, Cree AJ, Atkinson JP, Lotery AJ, Bubeck D, Morgan BP, Marchbank KJ, Seddon JM, Kavanagh D. McMahon O, et al. Among authors: hallam tm. Hum Mol Genet. 2021 Jun 17;30(13):1188-1199. doi: 10.1093/hmg/ddab086. Hum Mol Genet. 2021. PMID: 33783477 Free PMC article.
Insights Into the Structure-Function Relationships of Dimeric C3d Fragments.
Wahid AA, Dunphy RW, Macpherson A, Gibson BG, Kulik L, Whale K, Back C, Hallam TM, Alkhawaja B, Martin RL, Meschede I, Laabei M, Lawson ADG, Holers VM, Watts AG, Crennell SJ, Harris CL, Marchbank KJ, van den Elsen JMH. Wahid AA, et al. Among authors: hallam tm. Front Immunol. 2021 Aug 9;12:714055. doi: 10.3389/fimmu.2021.714055. eCollection 2021. Front Immunol. 2021. PMID: 34434196 Free PMC article.
Homodimeric Minimal Factor H: In Vivo Tracking and Extended Dosing Studies in Factor H Deficient Mice.
Kamala O, Malik TH, Hallam TM, Cox TE, Yang Y, Vyas F, Luli S, Connelly C, Gibson B, Smith-Jackson K, Denton H, Pappworth IY, Huang L, Kavanagh D, Pickering MC, Marchbank KJ. Kamala O, et al. Among authors: hallam tm. Front Immunol. 2021 Dec 9;12:752916. doi: 10.3389/fimmu.2021.752916. eCollection 2021. Front Immunol. 2021. PMID: 34956184 Free PMC article.
A novel method for real-time analysis of the complement C3b:FH:FI complex reveals dominant negative CFI variants in age-related macular degeneration.
Hallam TM, Cox TE, Smith-Jackson K, Brocklebank V, Baral AJ, Tzoumas N, Steel DH, Wong EKS, Shuttleworth VG, Lotery AJ, Harris CL, Marchbank KJ, Kavanagh D. Hallam TM, et al. Front Immunol. 2022 Dec 28;13:1028760. doi: 10.3389/fimmu.2022.1028760. eCollection 2022. Front Immunol. 2022. PMID: 36643920 Free PMC article.
13 results