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Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment in plaque-depositing mice.
Janssens J, Hermans B, Vandermeeren M, Barale-Thomas E, Borgers M, Willems R, Meulders G, Wintmolders C, Van den Bulck D, Bottelbergs A, Ver Donck L, Larsen P, Moechars D, Edwards W, Mercken M, Van Broeck B. Janssens J, et al. Among authors: hermans b. Neurobiol Dis. 2021 Jul;154:105365. doi: 10.1016/j.nbd.2021.105365. Epub 2021 Apr 10. Neurobiol Dis. 2021. PMID: 33848635 Free article.
Pharmacological profile of JNJ-27141491 [(S)-3-[3,4-difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl acid methyl ester], as a noncompetitive and orally active antagonist of the human chemokine receptor CCR2.
Buntinx M, Hermans B, Goossens J, Moechars D, Gilissen RA, Doyon J, Boeckx S, Coesemans E, Van Lommen G, Van Wauwe JP. Buntinx M, et al. Among authors: hermans b. J Pharmacol Exp Ther. 2008 Oct;327(1):1-9. doi: 10.1124/jpet.108.140723. Epub 2008 Jul 3. J Pharmacol Exp Ther. 2008. PMID: 18599682
2-Mercaptoimidazoles, a new class of potent CCR2 antagonists.
Van Lomen G, Doyon J, Coesemans E, Boeckx S, Cools M, Buntinx M, Hermans B, Van Wauwe J. Van Lomen G, et al. Among authors: hermans b. Bioorg Med Chem Lett. 2005 Feb 1;15(3):497-500. doi: 10.1016/j.bmcl.2004.11.064. Bioorg Med Chem Lett. 2005. PMID: 15729771
113 results