Kahlig KM - Search Results

1

Discovery of the First Orally Available, Selective K_Na1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series.

Griffin AM, Kahlig KM, Hatch RJ, Hughes ZA, Chapman ML, Antonio B, Marron BE, Wittmann M, Martinez-Botella G. Griffin AM, et al. Among authors: kahlig km. ACS Med Chem Lett. 2021 Mar 9;12(4):593-602. doi: 10.1021/acsmedchemlett.0c00675. eCollection 2021 Apr 8. ACS Med Chem Lett. 2021. PMID: 33859800 Free PMC article.

2

The novel persistent sodium current inhibitor PRAX-562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers.

Kahlig KM, Scott L, Hatch RJ, Griffin A, Martinez Botella G, Hughes ZA, Wittmann M. Kahlig KM, et al. Epilepsia. 2022 Mar;63(3):697-708. doi: 10.1111/epi.17149. Epub 2022 Jan 17. Epilepsia. 2022. PMID: 35037706 Free PMC article.

3

SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs.

Thompson CH, Kahlig KM, George AL Jr. Thompson CH, et al. Among authors: kahlig km. Epilepsia. 2011 May;52(5):1000-9. doi: 10.1111/j.1528-1167.2011.03040.x. Epub 2011 Mar 31. Epilepsia. 2011. PMID: 21453355 Free PMC article.

4

Nonfunctional SCN1A is common in severe myoclonic epilepsy of infancy.

Ohmori I, Kahlig KM, Rhodes TH, Wang DW, George AL Jr. Ohmori I, et al. Among authors: kahlig km. Epilepsia. 2006 Oct;47(10):1636-42. doi: 10.1111/j.1528-1167.2006.00643.x. Epilepsia. 2006. PMID: 17054685 Free article.

5

Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures.

Misra SN, Kahlig KM, George AL Jr. Misra SN, et al. Among authors: kahlig km. Epilepsia. 2008 Sep;49(9):1535-45. doi: 10.1111/j.1528-1167.2008.01619.x. Epub 2008 Apr 21. Epilepsia. 2008. PMID: 18479388 Free PMC article.

6

Ranolazine selectively blocks persistent current evoked by epilepsy-associated Naν1.1 mutations.

Kahlig KM, Lepist I, Leung K, Rajamani S, George AL. Kahlig KM, et al. Br J Pharmacol. 2010 Nov;161(6):1414-26. doi: 10.1111/j.1476-5381.2010.00976.x. Br J Pharmacol. 2010. PMID: 20735403 Free PMC article.

7

Divergent sodium channel defects in familial hemiplegic migraine.

Kahlig KM, Rhodes TH, Pusch M, Freilinger T, Pereira-Monteiro JM, Ferrari MD, van den Maagdenberg AM, Dichgans M, George AL Jr. Kahlig KM, et al. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9799-804. doi: 10.1073/pnas.0711717105. Epub 2008 Jul 9. Proc Natl Acad Sci U S A. 2008. PMID: 18621678 Free PMC article.

8

Multiplexed transposon-mediated stable gene transfer in human cells.

Kahlig KM, Saridey SK, Kaja A, Daniels MA, George AL Jr, Wilson MH. Kahlig KM, et al. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1343-8. doi: 10.1073/pnas.0910383107. Epub 2010 Jan 6. Proc Natl Acad Sci U S A. 2010. PMID: 20080581 Free PMC article.

9

Nontruncating SCN1A mutations associated with severe myoclonic epilepsy of infancy impair cell surface expression.

Thompson CH, Porter JC, Kahlig KM, Daniels MA, George AL Jr. Thompson CH, et al. Among authors: kahlig km. J Biol Chem. 2012 Dec 7;287(50):42001-8. doi: 10.1074/jbc.M112.421883. Epub 2012 Oct 19. J Biol Chem. 2012. PMID: 23086956 Free PMC article.

10

Ranolazine reduces neuronal excitability by interacting with inactivated states of brain sodium channels.

Kahlig KM, Hirakawa R, Liu L, George AL Jr, Belardinelli L, Rajamani S. Kahlig KM, et al. Mol Pharmacol. 2014 Jan;85(1):162-74. doi: 10.1124/mol.113.088492. Epub 2013 Nov 7. Mol Pharmacol. 2014. PMID: 24202911

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