El-Kasaby A - Search Results

1

Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters.

Bhat S, Guthrie DA, Kasture A, El-Kasaby A, Cao J, Bonifazi A, Ku T, Giancola JB, Hummel T, Freissmuth M, Newman AH. Bhat S, et al. ACS Pharmacol Transl Sci. 2020 Aug 28;4(2):503-516. doi: 10.1021/acsptsci.0c00102. eCollection 2021 Apr 9. ACS Pharmacol Transl Sci. 2020. PMID: 33860180 Free PMC article.

2

Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter.

El-Kasaby A, Just H, Malle E, Stolt-Bergner PC, Sitte HH, Freissmuth M, Kudlacek O. El-Kasaby A, et al. J Biol Chem. 2010 Dec 10;285(50):39201-10. doi: 10.1074/jbc.M110.118000. Epub 2010 Oct 2. J Biol Chem. 2010. PMID: 20889976 Free PMC article.

3

The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C.

Sucic S, El-Kasaby A, Kudlacek O, Sarker S, Sitte HH, Marin P, Freissmuth M. Sucic S, et al. J Biol Chem. 2011 May 6;286(18):16482-90. doi: 10.1074/jbc.M111.230037. Epub 2011 Mar 17. J Biol Chem. 2011. PMID: 21454670 Free PMC article.

4

Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C.

Sucic S, Koban F, El-Kasaby A, Kudlacek O, Stockner T, Sitte HH, Freissmuth M. Sucic S, et al. J Biol Chem. 2013 Feb 22;288(8):5330-41. doi: 10.1074/jbc.M112.408237. Epub 2013 Jan 3. J Biol Chem. 2013. PMID: 23288844 Free PMC article.

5

A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter.

El-Kasaby A, Koban F, Sitte HH, Freissmuth M, Sucic S. El-Kasaby A, et al. J Biol Chem. 2014 Oct 17;289(42):28987-9000. doi: 10.1074/jbc.M114.595090. Epub 2014 Sep 8. J Biol Chem. 2014. PMID: 25202009 Free PMC article.

6

A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.

Koban F, El-Kasaby A, Häusler C, Stockner T, Simbrunner BM, Sitte HH, Freissmuth M, Sucic S. Koban F, et al. J Biol Chem. 2015 May 22;290(21):13263-78. doi: 10.1074/jbc.M115.641357. Epub 2015 Apr 13. J Biol Chem. 2015. PMID: 25869136 Free PMC article.

7

Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones.

Kasture A, El-Kasaby A, Szöllősi D, Asjad HMM, Grimm A, Stockner T, Hummel T, Freissmuth M, Sucic S. Kasture A, et al. J Biol Chem. 2016 Sep 30;291(40):20876-20890. doi: 10.1074/jbc.M116.737551. Epub 2016 Aug 1. J Biol Chem. 2016. PMID: 27481941 Free PMC article.

8

The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter.

Kern C, Erdem FA, El-Kasaby A, Sandtner W, Freissmuth M, Sucic S. Kern C, et al. J Biol Chem. 2017 Mar 3;292(9):3603-3613. doi: 10.1074/jbc.M116.771360. Epub 2017 Jan 19. J Biol Chem. 2017. PMID: 28104804 Free PMC article.

9

When transporters fail to be transported: how to rescue folding-deficient SLC6 transporters.

Sucic S, Kasture A, Mazhar Asjad HM, Kern C, El-Kasaby A, Freissmuth M. Sucic S, et al. J Neurol Neuromedicine. 2016 Dec 30;1(9):34-40. doi: 10.29245/2572.942x/2016/9.1098. J Neurol Neuromedicine. 2016. PMID: 28405636 Free PMC article.

10

Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates.

Bhat S, Hasenhuetl PS, Kasture A, El-Kasaby A, Baumann MH, Blough BE, Sucic S, Sandtner W, Freissmuth M. Bhat S, et al. J Biol Chem. 2017 Oct 6;292(40):16773-16786. doi: 10.1074/jbc.M117.794081. Epub 2017 Aug 23. J Biol Chem. 2017. PMID: 28842491 Free PMC article.

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