Kuschak M - Search Results

1

Macrocyclic Gq Protein Inhibitors FR900359 and/or YM-254890-Fit for Translation?

Schlegel JG, Tahoun M, Seidinger A, Voss JH, Kuschak M, Kehraus S, Schneider M, Matthey M, Fleischmann BK, König GM, Wenzel D, Müller CE. Schlegel JG, et al. Among authors: kuschak m. ACS Pharmacol Transl Sci. 2021 Feb 19;4(2):888-897. doi: 10.1021/acsptsci.1c00021. eCollection 2021 Apr 9. ACS Pharmacol Transl Sci. 2021. PMID: 33860209 Free PMC article.

2

Targeted inhibition of G_q signaling induces airway relaxation in mouse models of asthma.

Matthey M, Roberts R, Seidinger A, Simon A, Schröder R, Kuschak M, Annala S, König GM, Müller CE, Hall IP, Kostenis E, Fleischmann BK, Wenzel D. Matthey M, et al. Among authors: kuschak m. Sci Transl Med. 2017 Sep 13;9(407):eaag2288. doi: 10.1126/scitranslmed.aag2288. Sci Transl Med. 2017. PMID: 28904224

3

Cell-permeable high-affinity tracers for G_q proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.

Kuschak M, Namasivayam V, Rafehi M, Voss JH, Garg J, Schlegel JG, Abdelrahman A, Kehraus S, Reher R, Küppers J, Sylvester K, Hinz S, Matthey M, Wenzel D, Fleischmann BK, Pfeifer A, Inoue A, Gütschow M, König GM, Müller CE. Kuschak M, et al. Br J Pharmacol. 2020 Apr;177(8):1898-1916. doi: 10.1111/bph.14960. Epub 2020 Feb 11. Br J Pharmacol. 2020. PMID: 31881095 Free PMC article.

4

Sensitive LC-MS/MS Method for the Quantification of Macrocyclic Gα_q Protein Inhibitors in Biological Samples.

Kuschak M, Schlegel JG, Schneider M, Kehraus S, Voss JH, Seidinger A, Matthey M, Wenzel D, Fleischmann BK, König GM, Müller CE. Kuschak M, et al. Front Chem. 2020 Sep 24;8:833. doi: 10.3389/fchem.2020.00833. eCollection 2020. Front Chem. 2020. PMID: 33173765 Free PMC article.

5

Heterologous Expression, Biosynthetic Studies, and Ecological Function of the Selective Gq-Signaling Inhibitor FR900359.

Crüsemann M, Reher R, Schamari I, Brachmann AO, Ohbayashi T, Kuschak M, Malfacini D, Seidinger A, Pinto-Carbó M, Richarz R, Reuter T, Kehraus S, Hallab A, Attwood M, Schiöth HB, Mergaert P, Kikuchi Y, Schäberle TF, Kostenis E, Wenzel D, Müller CE, Piel J, Carlier A, Eberl L, König GM. Crüsemann M, et al. Among authors: kuschak m. Angew Chem Int Ed Engl. 2018 Jan 15;57(3):836-840. doi: 10.1002/anie.201707996. Epub 2017 Dec 20. Angew Chem Int Ed Engl. 2018. PMID: 29194875

6

Applying Molecular Networking for the Detection of Natural Sources and Analogues of the Selective Gq Protein Inhibitor FR900359.

Reher R, Kuschak M, Heycke N, Annala S, Kehraus S, Dai HF, Müller CE, Kostenis E, König GM, Crüsemann M. Reher R, et al. Among authors: kuschak m. J Nat Prod. 2018 Jul 27;81(7):1628-1635. doi: 10.1021/acs.jnatprod.8b00222. Epub 2018 Jun 26. J Nat Prod. 2018. PMID: 29943987

7

Toxic pyrrolizidinalkaloids as undesired contaminants in food and feed: degradation of the PAs from Senecio jacobaea in silage.

Becerra-Jiminez J, Kuschak M, Roeder E, Wiedenfeld H. Becerra-Jiminez J, et al. Among authors: kuschak m. Pharmazie. 2013 Jul;68(7):636-9. Pharmazie. 2013. PMID: 23923650

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