Spratt DE - Search Results

1

Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response.

Mathieu NA, Levin RH, Spratt DE. Mathieu NA, et al. Among authors: spratt de. Front Oncol. 2021 Mar 31;11:659049. doi: 10.3389/fonc.2021.659049. eCollection 2021. Front Oncol. 2021. PMID: 33869064 Free PMC article. Review.

2

¹H, ¹³C, and ¹⁵N resonance assignments of the C-terminal lobe of the human HECT E3 ubiquitin ligase ITCH.

Beasley SA, Bardhi R, Spratt DE. Beasley SA, et al. Among authors: spratt de. Biomol NMR Assign. 2019 Apr;13(1):15-20. doi: 10.1007/s12104-018-9843-2. Epub 2018 Sep 18. Biomol NMR Assign. 2019. PMID: 30229450 Free PMC article.

3

Crystal structure of the catalytic C-lobe of the HECT-type ubiquitin ligase E6AP.

Ries LK, Liess AKL, Feiler CG, Spratt DE, Lowe ED, Lorenz S. Ries LK, et al. Among authors: spratt de. Protein Sci. 2020 Jun;29(6):1550-1554. doi: 10.1002/pro.3832. Epub 2020 Feb 5. Protein Sci. 2020. PMID: 31994269 Free PMC article.

4

HECT E3 ubiquitin ligases - emerging insights into their biological roles and disease relevance.

Wang Y, Argiles-Castillo D, Kane EI, Zhou A, Spratt DE. Wang Y, et al. Among authors: spratt de. J Cell Sci. 2020 Apr 7;133(7):jcs228072. doi: 10.1242/jcs.228072. J Cell Sci. 2020. PMID: 32265230 Free PMC article. Review.

5

An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity.

Beasley SA, Kellum CE, Orlomoski RJ, Idrizi F, Spratt DE. Beasley SA, et al. Among authors: spratt de. PLoS One. 2020 Jul 8;15(7):e0235925. doi: 10.1371/journal.pone.0235925. eCollection 2020. PLoS One. 2020. PMID: 32639967 Free PMC article.

6

HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune Response.

Mathieu NA, Paparisto E, Barr SD, Spratt DE. Mathieu NA, et al. Among authors: spratt de. Viruses. 2021 Jun 9;13(6):1102. doi: 10.3390/v13061102. Viruses. 2021. PMID: 34207696 Free PMC article. Review.

7

Redefining the catalytic HECT domain boundaries for the HECT E3 ubiquitin ligase family.

Kane EI, Beasley SA, Schafer JM, Bohl JE, Lee YS, Rich KJ, Bosia EF, Spratt DE. Kane EI, et al. Among authors: spratt de. Biosci Rep. 2022 Oct 28;42(10):BSR20221036. doi: 10.1042/BSR20221036. Biosci Rep. 2022. PMID: 36111624 Free PMC article.

8

The disordered negatively charged C-terminus of the large HECT E3 ubiquitin ligase HERC2 provides structural and thermal stability to the HECT C-lobe.

Waters KL, Rich KJ, Schwaegerle ND, Yang T, Huo S, Spratt DE. Waters KL, et al. Among authors: spratt de. Protein Sci. 2024 Dec;33(12):e5229. doi: 10.1002/pro.5229. Protein Sci. 2024. PMID: 39565083 Free PMC article.

9

New Discoveries on Protein Recruitment and Regulation during the Early Stages of the DNA Damage Response Pathways.

Waters KL, Spratt DE. Waters KL, et al. Among authors: spratt de. Int J Mol Sci. 2024 Jan 30;25(3):1676. doi: 10.3390/ijms25031676. Int J Mol Sci. 2024. PMID: 38338953 Free PMC article. Review.

10

Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation.

Kane EI, Spratt DE. Kane EI, et al. Among authors: spratt de. Int J Mol Sci. 2021 Jan 9;22(2):609. doi: 10.3390/ijms22020609. Int J Mol Sci. 2021. PMID: 33435370 Free PMC article. Review.

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