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From High-Throughput Screening to Target Validation: Benzo[d]isothiazoles as Potent and Selective Agonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 5 Possessing In Vivo Gastrointestinal Prokinetic Activity in Rodents.
Barilli A, Aldegheri L, Bianchi F, Brault L, Brodbeck D, Castelletti L, Feriani A, Lingard I, Myers R, Nola S, Piccoli L, Pompilio D, Raveglia LF, Salvagno C, Tassini S, Virginio C, Sabat M. Barilli A, et al. Among authors: brodbeck d. J Med Chem. 2021 May 13;64(9):5931-5955. doi: 10.1021/acs.jmedchem.1c00065. Epub 2021 Apr 23. J Med Chem. 2021. PMID: 33890770
The discovery of (1R, 3R)-1-(3-chloro-5-fluorophenyl)-3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-6-carbonitrile, a potent and selective agonist of human transient receptor potential cation channel subfamily m member 5 (TRPM5) and evaluation of as a potential gastrointestinal prokinetic agent.
Sabat M, Raveglia LF, Aldegheri L, Barilli A, Bianchi F, Brault L, Brodbeck D, Feriani A, Lingard I, Miura J, Myers R, Piccoli L, Tassini S, Tyhonas J, Ton-Nu T, Wang H, Virginio C. Sabat M, et al. Among authors: brodbeck d. Bioorg Med Chem. 2022 Dec 15;76:117084. doi: 10.1016/j.bmc.2022.117084. Epub 2022 Nov 6. Bioorg Med Chem. 2022. PMID: 36402081
ICU Cockpit: a platform for collecting multimodal waveform data, AI-based computational disease modeling and real-time decision support in the intensive care unit.
Boss JM, Narula G, Straessle C, Willms J, Azzati J, Brodbeck D, Luethy R, Suter S, Buehler C, Muroi C, Mack DJ, Seric M, Baumann D, Keller E. Boss JM, et al. Among authors: brodbeck d. J Am Med Inform Assoc. 2022 Jun 14;29(7):1286-1291. doi: 10.1093/jamia/ocac064. J Am Med Inform Assoc. 2022. PMID: 35552418 Free PMC article.
RWD-Cockpit: Application for Quality Assessment of Real-world Data.
Babrak LM, Smakaj E, Agac T, Asprion PM, Grimberg F, der Werf DV, van Ginkel EW, Tosoni DD, Clay I, Degen M, Brodbeck D, Natali EN, Schkommodau E, Miho E. Babrak LM, et al. Among authors: brodbeck d. JMIR Form Res. 2022 Oct 18;6(10):e29920. doi: 10.2196/29920. JMIR Form Res. 2022. PMID: 35266872 Free PMC article.
33 results