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From High-Throughput Screening to Target Validation: Benzo[d]isothiazoles as Potent and Selective Agonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 5 Possessing In Vivo Gastrointestinal Prokinetic Activity in Rodents.
Barilli A, Aldegheri L, Bianchi F, Brault L, Brodbeck D, Castelletti L, Feriani A, Lingard I, Myers R, Nola S, Piccoli L, Pompilio D, Raveglia LF, Salvagno C, Tassini S, Virginio C, Sabat M. Barilli A, et al. Among authors: virginio c. J Med Chem. 2021 May 13;64(9):5931-5955. doi: 10.1021/acs.jmedchem.1c00065. Epub 2021 Apr 23. J Med Chem. 2021. PMID: 33890770
Characterization of three diaminopyrimidines as potent and selective antagonists of P2X3 and P2X2/3 receptors with in vivo efficacy in a pain model.
Ballini E, Virginio C, Medhurst SJ, Summerfield SG, Aldegheri L, Buson A, Carignani C, Chen YH, Giacometti A, Lago I, Powell AJ, Jarolimek W. Ballini E, et al. Among authors: virginio c. Br J Pharmacol. 2011 Jul;163(6):1315-25. doi: 10.1111/j.1476-5381.2011.01322.x. Br J Pharmacol. 2011. PMID: 21410458 Free PMC article.
A novel series of benzimidazole NR2B-selective NMDA receptor antagonists.
Davies DJ, Crowe M, Lucas N, Quinn J, Miller DD, Pritchard S, Grose D, Bettini E, Calcinaghi N, Virginio C, Abberley L, Goldsmith P, Michel AD, Chessell IP, Kew JN, Miller ND, Gunthorpe MJ. Davies DJ, et al. Among authors: virginio c. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2620-3. doi: 10.1016/j.bmcl.2012.01.108. Epub 2012 Feb 6. Bioorg Med Chem Lett. 2012. PMID: 22366657
Synthesis and biological activity of a novel class nicotinic acetylcholine receptors (nAChRs) ligands structurally related to anatoxin-a.
Simoni D, Rondanin R, Marchetti P, Rullo C, Baruchello R, Grisolia G, Barbato G, Giovannini R, Marchioro C, Capelli AM, Virginio C, Bozzoli A, Borea PA, Merighi S, Donati D. Simoni D, et al. Among authors: virginio c. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5423-7. doi: 10.1016/j.bmcl.2011.06.127. Epub 2011 Jul 20. Bioorg Med Chem Lett. 2011. PMID: 21824774
32 results