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Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling.
Mukhopadhyay A, Saddoughi SA, Song P, Sultan I, Ponnusamy S, Senkal CE, Snook CF, Arnold HK, Sears RC, Hannun YA, Ogretmen B. Mukhopadhyay A, et al. Among authors: ogretmen b. FASEB J. 2009 Mar;23(3):751-63. doi: 10.1096/fj.08-120550. Epub 2008 Nov 21. FASEB J. 2009. PMID: 19028839 Free PMC article.
Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction.
Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B. Meyers-Needham M, et al. Among authors: ogretmen b. Mol Cancer Ther. 2012 May;11(5):1092-102. doi: 10.1158/1535-7163.MCT-11-0705. Epub 2012 Mar 27. Mol Cancer Ther. 2012. PMID: 22452947 Free PMC article.
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, Bielawski J, Ogretmen B. Sentelle RD, et al. Among authors: ogretmen b. Nat Chem Biol. 2012 Oct;8(10):831-8. doi: 10.1038/nchembio.1059. Nat Chem Biol. 2012. PMID: 22922758 Free PMC article.
LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria.
Beckham TH, Lu P, Jones EE, Marrison T, Lewis CS, Cheng JC, Ramshesh VK, Beeson G, Beeson CC, Drake RR, Bielawska A, Bielawski J, Szulc ZM, Ogretmen B, Norris JS, Liu X. Beckham TH, et al. Among authors: ogretmen b. J Pharmacol Exp Ther. 2013 Jan;344(1):167-78. doi: 10.1124/jpet.112.199216. Epub 2012 Oct 18. J Pharmacol Exp Ther. 2013. PMID: 23086228 Free PMC article.
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.
Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, Habib AA, Stahelin RV, Perrotti D, Ogretmen B. Saddoughi SA, et al. Among authors: ogretmen b. EMBO Mol Med. 2013 Jan;5(1):105-21. doi: 10.1002/emmm.201201283. Epub 2012 Nov 25. EMBO Mol Med. 2013. PMID: 23180565 Free PMC article.
146 results