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Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic.
Zhang X, Luo M, Dastagir SR, Nixon M, Khamhoung A, Schmidt A, Lee A, Subbiah N, McLaughlin DC, Moore CL, Gribble M, Bayhi N, Amin V, Pepi R, Pawar S, Lyford TJ, Soman V, Mellen J, Carpenter CL, Turka LA, Wickham TJ, Chen TF. Zhang X, et al. Among authors: wickham tj. Nat Commun. 2021 May 11;12(1):2637. doi: 10.1038/s41467-021-22898-3. Nat Commun. 2021. PMID: 33976146 Free PMC article.
Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15.
McArdel SL, Dugast AS, Hoover ME, Bollampalli A, Hong E, Castano Z, Leonard SC, Pawar S, Mellen J, Muriuki K, McLaughlin DC, Bayhi N, Carpenter CL, Turka LA, Wickham TJ, Elloul S. McArdel SL, et al. Among authors: wickham tj. Cancer Immunol Immunother. 2021 Sep;70(9):2701-2719. doi: 10.1007/s00262-021-03001-7. Epub 2021 Jul 9. Cancer Immunol Immunother. 2021. PMID: 34244816 Free PMC article.
HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity.
Reynolds JG, Geretti E, Hendriks BS, Lee H, Leonard SC, Klinz SG, Noble CO, Lücker PB, Zandstra PW, Drummond DC, Olivier KJ Jr, Nielsen UB, Niyikiza C, Agresta SV, Wickham TJ. Reynolds JG, et al. Among authors: wickham tj. Toxicol Appl Pharmacol. 2012 Jul 1;262(1):1-10. doi: 10.1016/j.taap.2012.04.008. Epub 2012 Apr 21. Toxicol Appl Pharmacol. 2012. PMID: 22676972
Multiscale kinetic modeling of liposomal Doxorubicin delivery quantifies the role of tumor and drug-specific parameters in local delivery to tumors.
Hendriks BS, Reynolds JG, Klinz SG, Geretti E, Lee H, Leonard SC, Gaddy DF, Espelin CW, Nielsen UB, Wickham TJ. Hendriks BS, et al. Among authors: wickham tj. CPT Pharmacometrics Syst Pharmacol. 2012 Nov 21;1(11):e15. doi: 10.1038/psp.2012.16. CPT Pharmacometrics Syst Pharmacol. 2012. PMID: 23835797 Free PMC article.
64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer.
Lee H, Shields AF, Siegel BA, Miller KD, Krop I, Ma CX, LoRusso PM, Munster PN, Campbell K, Gaddy DF, Leonard SC, Geretti E, Blocker SJ, Kirpotin DB, Moyo V, Wickham TJ, Hendriks BS. Lee H, et al. Among authors: wickham tj. Clin Cancer Res. 2017 Aug 1;23(15):4190-4202. doi: 10.1158/1078-0432.CCR-16-3193. Epub 2017 Mar 15. Clin Cancer Res. 2017. PMID: 28298546 Free PMC article. Clinical Trial.
78 results