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3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration.
Wang H, Brown PC, Chow ECY, Ewart L, Ferguson SS, Fitzpatrick S, Freedman BS, Guo GL, Hedrich W, Heyward S, Hickman J, Isoherranen N, Li AP, Liu Q, Mumenthaler SM, Polli J, Proctor WR, Ribeiro A, Wang JY, Wange RL, Huang SM. Wang H, et al. Among authors: isoherranen n. Clin Transl Sci. 2021 Sep;14(5):1659-1680. doi: 10.1111/cts.13066. Epub 2021 Jun 16. Clin Transl Sci. 2021. PMID: 33982436 Free PMC article. Review.
Gut commensals expand vitamin A metabolic capacity of the mammalian host.
Bonakdar M, Czuba LC, Han G, Zhong G, Luong H, Isoherranen N, Vaishnava S. Bonakdar M, et al. Among authors: isoherranen n. Cell Host Microbe. 2022 Aug 10;30(8):1084-1092.e5. doi: 10.1016/j.chom.2022.06.011. Epub 2022 Jul 20. Cell Host Microbe. 2022. PMID: 35863343 Free PMC article.
Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein (FABP1) and FABP1 Binding Alters Drug Metabolism.
Yabut KCB, Martynova A, Nath A, Zercher BP, Bush MF, Isoherranen N. Yabut KCB, et al. Among authors: isoherranen n. bioRxiv [Preprint]. 2024 Jan 19:2024.01.17.576032. doi: 10.1101/2024.01.17.576032. bioRxiv. 2024. Update in: Mol Pharmacol. 2024 May 17;105(6):395-410. doi: 10.1124/molpharm.124.000878 PMID: 38293009 Free PMC article. Updated. Preprint.
CYP2D6 Activity Is Correlated with Changes in Plasma Concentrations of Taurocholic Acid during Pregnancy and Postpartum in CYP2D6 Extensive Metabolizers.
Czuba LC, Malhotra K, Enthoven L, Fay EE, Moreni SL, Mao J, Shi Y, Huang W, Totah RA, Isoherranen N, Hebert MF. Czuba LC, et al. Among authors: isoherranen n. Drug Metab Dispos. 2023 Nov;51(11):1474-1482. doi: 10.1124/dmd.123.001358. Epub 2023 Aug 7. Drug Metab Dispos. 2023. PMID: 37550070 Free PMC article.
Altered vitamin A metabolism in human liver slices corresponds to fibrogenesis.
Czuba LC, Wu X, Huang W, Hollingshead N, Roberto JB, Kenerson HL, Yeung RS, Crispe IN, Isoherranen N. Czuba LC, et al. Among authors: isoherranen n. Clin Transl Sci. 2021 May;14(3):976-989. doi: 10.1111/cts.12962. Epub 2021 Feb 2. Clin Transl Sci. 2021. PMID: 33382909 Free PMC article.
171 results