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Page 1
Lupus Susceptibility Region Containing CDKN1B rs34330 Mechanistically Influences Expression and Function of Multiple Target Genes, Also Linked to Proliferation and Apoptosis.
Singh B, Maiti GP, Zhou X, Fazel-Najafabadi M, Bae SC, Sun C, Terao C, Okada Y, Heng Chua K, Kochi Y, Guthridge JM, Zhang H, Weirauch M, James JA, Harley JB, Varshney GK, Looger LL, Nath SK. Singh B, et al. Among authors: fazel najafabadi m. Arthritis Rheumatol. 2021 Dec;73(12):2303-2313. doi: 10.1002/art.41799. Epub 2021 Oct 29. Arthritis Rheumatol. 2021. PMID: 33982894 Free PMC article.
Connecting omics signatures and revealing biological mechanisms with iLINCS.
Pilarczyk M, Fazel-Najafabadi M, Kouril M, Shamsaei B, Vasiliauskas J, Niu W, Mahi N, Zhang L, Clark NA, Ren Y, White S, Karim R, Xu H, Biesiada J, Bennett MF, Davidson SE, Reichard JF, Roberts K, Stathias V, Koleti A, Vidovic D, Clarke DJB, Schürer SC, Ma'ayan A, Meller J, Medvedovic M. Pilarczyk M, et al. Among authors: fazel najafabadi m. Nat Commun. 2022 Aug 9;13(1):4678. doi: 10.1038/s41467-022-32205-3. Nat Commun. 2022. PMID: 35945222 Free PMC article.
LINCS Data Portal 2.0: next generation access point for perturbation-response signatures.
Stathias V, Turner J, Koleti A, Vidovic D, Cooper D, Fazel-Najafabadi M, Pilarczyk M, Terryn R, Chung C, Umeano A, Clarke DJB, Lachmann A, Evangelista JE, Ma'ayan A, Medvedovic M, Schürer SC. Stathias V, et al. Among authors: fazel najafabadi m. Nucleic Acids Res. 2020 Jan 8;48(D1):D431-D439. doi: 10.1093/nar/gkz1023. Nucleic Acids Res. 2020. PMID: 31701147 Free PMC article.
Accelerating drug discovery and repurposing by combining transcriptional signature connectivity with docking.
Thorman AW, Reigle J, Chutipongtanate S, Yang J, Shamsaei B, Pilarczyk M, Fazel-Najafabadi M, Adamczak R, Kouril M, Bhatnagar S, Hummel S, Niu W, Morrow AL, Czyzyk-Krzeska MF, McCullumsmith R, Seibel W, Nassar N, Zheng Y, Hildeman DA, Medvedovic M, Herr AB, Meller J. Thorman AW, et al. Among authors: fazel najafabadi m. Sci Adv. 2024 Aug 30;10(35):eadj3010. doi: 10.1126/sciadv.adj3010. Epub 2024 Aug 30. Sci Adv. 2024. PMID: 39213358 Free PMC article.
A Non-Coding Variant in SLC15A4 Modulates Enhancer Activity and Lysosomal Deacidification Linked to Lupus Susceptibility.
Singh MK, Maiti GP, Reddy-Rallabandi H, Fazel-Najafabadi M, Looger LL, Nath SK. Singh MK, et al. Among authors: fazel najafabadi m. bioRxiv [Preprint]. 2023 Sep 2:2023.07.28.551056. doi: 10.1101/2023.07.28.551056. bioRxiv. 2023. Update in: Front Lupus. 2023;1:1244670. doi: 10.3389/flupu.2023.1244670. PMID: 37546883 Free PMC article. Updated. Preprint.