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A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease.
Nishikawa T, Bellance N, Damm A, Bing H, Zhu Z, Handa K, Yovchev MI, Sehgal V, Moss TJ, Oertel M, Ram PT, Pipinos II, Soto-Gutierrez A, Fox IJ, Nagrath D. Nishikawa T, et al. J Hepatol. 2014 Jun;60(6):1203-11. doi: 10.1016/j.jhep.2014.02.014. Epub 2014 Feb 26. J Hepatol. 2014. PMID: 24583248 Free PMC article.
Resetting the transcription factor network reverses terminal chronic hepatic failure.
Nishikawa T, Bell A, Brooks JM, Setoyama K, Melis M, Han B, Fukumitsu K, Handa K, Tian J, Kaestner KH, Vodovotz Y, Locker J, Soto-Gutierrez A, Fox IJ. Nishikawa T, et al. J Clin Invest. 2015 Apr;125(4):1533-44. doi: 10.1172/JCI73137. Epub 2015 Mar 16. J Clin Invest. 2015. PMID: 25774505 Free PMC article.
Clinical Hepatocyte Transplantation: What Is Next?
Squires JE, Soltys KA, McKiernan P, Squires RH, Strom SC, Fox IJ, Soto-Gutierrez A. Squires JE, et al. Curr Transplant Rep. 2017 Dec;4(4):280-289. doi: 10.1007/s40472-017-0165-6. Epub 2017 Oct 14. Curr Transplant Rep. 2017. PMID: 29732274 Free PMC article.
Liver-enriched transcription factor expression relates to chronic hepatic failure in humans.
Guzman-Lepe J, Cervantes-Alvarez E, Collin de l'Hortet A, Wang Y, Mars WM, Oda Y, Bekki Y, Shimokawa M, Wang H, Yoshizumi T, Maehara Y, Bell A, Fox IJ, Takeishi K, Soto-Gutierrez A. Guzman-Lepe J, et al. Hepatol Commun. 2018 Mar 23;2(5):582-594. doi: 10.1002/hep4.1172. eCollection 2018 May. Hepatol Commun. 2018. PMID: 29761173 Free PMC article.
Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans.
Florentino RM, Fraunhoffer NA, Morita K, Takeishi K, Ostrowska A, Achreja A, Animasahun O, Haep N, Arazov S, Agarwal N, Collin de l'Hortet A, Guzman-Lepe J, Tafaleng EN, Mukherjee A, Troy K, Banerjee S, Paranjpe S, Michalopoulos GK, Bell A, Nagrath D, Hainer SJ, Fox IJ, Soto-Gutierrez A. Florentino RM, et al. Hepatol Commun. 2020 Apr 21;4(6):859-875. doi: 10.1002/hep4.1505. eCollection 2020 Jun. Hepatol Commun. 2020. PMID: 32490322 Free PMC article.
Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells.
Takeishi K, Collin de l'Hortet A, Wang Y, Handa K, Guzman-Lepe J, Matsubara K, Morita K, Jang S, Haep N, Florentino RM, Yuan F, Fukumitsu K, Tobita K, Sun W, Franks J, Delgado ER, Shapiro EM, Fraunhoffer NA, Duncan AW, Yagi H, Mashimo T, Fox IJ, Soto-Gutierrez A. Takeishi K, et al. Cell Rep. 2020 Jun 2;31(9):107711. doi: 10.1016/j.celrep.2020.107711. Cell Rep. 2020. PMID: 32492423 Free PMC article.
Molecular overview of progressive familial intrahepatic cholestasis.
Amirneni S, Haep N, Gad MA, Soto-Gutierrez A, Squires JE, Florentino RM. Amirneni S, et al. World J Gastroenterol. 2020 Dec 21;26(47):7470-7484. doi: 10.3748/wjg.v26.i47.7470. World J Gastroenterol. 2020. PMID: 33384548 Free PMC article. Review.
117 results