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Page 1
UCP1 governs liver extracellular succinate and inflammatory pathogenesis.
Mills EL, Harmon C, Jedrychowski MP, Xiao H, Garrity R, Tran NV, Bradshaw GA, Fu A, Szpyt J, Reddy A, Prendeville H, Danial NN, Gygi SP, Lynch L, Chouchani ET. Mills EL, et al. Among authors: garrity r. Nat Metab. 2021 May;3(5):604-617. doi: 10.1038/s42255-021-00389-5. Epub 2021 May 17. Nat Metab. 2021. PMID: 34002097 Free PMC article. Review.
Accumulation of succinate controls activation of adipose tissue thermogenesis.
Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET. Mills EL, et al. Among authors: garrity r. Nature. 2018 Aug;560(7716):102-106. doi: 10.1038/s41586-018-0353-2. Epub 2018 Jul 18. Nature. 2018. PMID: 30022159 Free PMC article.
H+ transport is an integral function of the mitochondrial ADP/ATP carrier.
Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y. Bertholet AM, et al. Among authors: garrity r. Nature. 2019 Jul;571(7766):515-520. doi: 10.1038/s41586-019-1400-3. Epub 2019 Jul 24. Nature. 2019. PMID: 31341297 Free PMC article.
A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging.
Xiao H, Jedrychowski MP, Schweppe DK, Huttlin EL, Yu Q, Heppner DE, Li J, Long J, Mills EL, Szpyt J, He Z, Du G, Garrity R, Reddy A, Vaites LP, Paulo JA, Zhang T, Gray NS, Gygi SP, Chouchani ET. Xiao H, et al. Among authors: garrity r. Cell. 2020 Mar 5;180(5):968-983.e24. doi: 10.1016/j.cell.2020.02.012. Epub 2020 Feb 27. Cell. 2020. PMID: 32109415 Free PMC article.
Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity.
Jedrychowski MP, Lu GZ, Szpyt J, Mariotti M, Garrity R, Paulo JA, Schweppe DK, Laznik-Bogoslavski D, Kazak L, Murphy MP, Gladyshev VN, Gygi SP, Chouchani ET, Spiegelman BM. Jedrychowski MP, et al. Among authors: garrity r. Proc Natl Acad Sci U S A. 2020 May 19;117(20):10789-10796. doi: 10.1073/pnas.2001387117. Epub 2020 May 1. Proc Natl Acad Sci U S A. 2020. PMID: 32358195 Free PMC article.
pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise.
Reddy A, Bozi LHM, Yaghi OK, Mills EL, Xiao H, Nicholson HE, Paschini M, Paulo JA, Garrity R, Laznik-Bogoslavski D, Ferreira JCB, Carl CS, Sjøberg KA, Wojtaszewski JFP, Jeppesen JF, Kiens B, Gygi SP, Richter EA, Mathis D, Chouchani ET. Reddy A, et al. Among authors: garrity r. Cell. 2020 Oct 1;183(1):62-75.e17. doi: 10.1016/j.cell.2020.08.039. Epub 2020 Sep 17. Cell. 2020. PMID: 32946811 Free PMC article.
Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.
Mills EL, Harmon C, Jedrychowski MP, Xiao H, Gruszczyk AV, Bradshaw GA, Tran N, Garrity R, Laznik-Bogoslavski D, Szpyt J, Prendeville H, Lynch L, Murphy MP, Gygi SP, Spiegelman BM, Chouchani ET. Mills EL, et al. Among authors: garrity r. Cell Metab. 2022 Jan 4;34(1):140-157.e8. doi: 10.1016/j.cmet.2021.11.003. Epub 2021 Dec 2. Cell Metab. 2022. PMID: 34861155 Free PMC article.
Mitochondrial uncouplers induce proton leak by activating AAC and UCP1.
Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y. Bertholet AM, et al. Among authors: garrity r. Nature. 2022 Jun;606(7912):180-187. doi: 10.1038/s41586-022-04747-5. Epub 2022 May 25. Nature. 2022. PMID: 35614225 Free PMC article.
Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.
Xiao H, Bozi LHM, Sun Y, Riley CL, Philip VM, Chen M, Li J, Zhang T, Mills EL, Emont MP, Sun W, Reddy A, Garrity R, Long J, Becher T, Vitas LP, Laznik-Bogoslavski D, Ordonez M, Liu X, Chen X, Wang Y, Liu W, Tran N, Liu Y, Zhang Y, Cypess AM, White AP, He Y, Deng R, Schöder H, Paulo JA, Jedrychowski MP, Banks AS, Tseng YH, Cohen P, Tsai LT, Rosen ED, Klein S, Chondronikola M, McAllister FE, Van Bruggen N, Huttlin EL, Spiegelman BM, Churchill GA, Gygi SP, Chouchani ET. Xiao H, et al. Among authors: garrity r. Cell. 2022 Nov 23;185(24):4654-4673.e28. doi: 10.1016/j.cell.2022.10.003. Epub 2022 Nov 4. Cell. 2022. PMID: 36334589 Free PMC article.
36 results