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Selective Inhibition of DNA Polymerase β by a Covalent Inhibitor.
Yuhas SC, Laverty DJ, Lee H, Majumdar A, Greenberg MM. Yuhas SC, et al. Among authors: laverty dj. J Am Chem Soc. 2021 Jun 2;143(21):8099-8107. doi: 10.1021/jacs.1c02453. Epub 2021 May 20. J Am Chem Soc. 2021. PMID: 34014094 Free PMC article.
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, Nagel ZD, Ellenberger T, Kim IK, Jones DE, Ahmed Z, Tainer JA. Houl JH, et al. Nat Commun. 2019 Dec 11;10(1):5654. doi: 10.1038/s41467-019-13508-4. Nat Commun. 2019. PMID: 31827085 Free PMC article.
An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
Nguyen MT, Moiani D, Ahmed Z, Arvai AS, Namjoshi S, Shin DS, Fedorov Y, Selvik EJ, Jones DE, Pink J, Yan Y, Laverty DJ, Nagel ZD, Tainer JA, Gerson SL. Nguyen MT, et al. Among authors: laverty dj. Prog Biophys Mol Biol. 2021 Aug;163:143-159. doi: 10.1016/j.pbiomolbio.2021.02.004. Epub 2021 Mar 3. Prog Biophys Mol Biol. 2021. PMID: 33675849 Free PMC article.
Differential immunomodulatory effect of PARP inhibition in BRCA1 deficient and competent tumor cells.
Alvarado-Cruz I, Mahmoud M, Khan M, Zhao S, Oeck S, Meas R, Clairmont K, Quintana V, Zhu Y, Porciuncula A, Wyatt H, Ma S, Shyr Y, Kong Y, LoRusso PM, Laverty D, Nagel ZD, Schalper KA, Krauthammer M, Sweasy JB. Alvarado-Cruz I, et al. Biochem Pharmacol. 2021 Feb;184:114359. doi: 10.1016/j.bcp.2020.114359. Epub 2020 Dec 4. Biochem Pharmacol. 2021. PMID: 33285109 Free PMC article.
21 results