Crowell SR - Search Results

1

Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics.

Shivva V, Boswell CA, Rafidi H, Kelley RF, Kamath AV, Crowell SR. Shivva V, et al. Among authors: crowell sr. Front Pharmacol. 2021 May 6;12:601569. doi: 10.3389/fphar.2021.601569. eCollection 2021. Front Pharmacol. 2021. PMID: 34025395 Free PMC article.

2

Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation.

Gong Q, Hazen M, Marshall B, Crowell SR, Ou Q, Wong AW, Phung W, Vernes JM, Meng YG, Tejada M, Andersen D, Kelley RF. Gong Q, et al. Among authors: crowell sr. MAbs. 2016 Aug-Sep;8(6):1098-106. doi: 10.1080/19420862.2016.1189049. Epub 2016 May 24. MAbs. 2016. PMID: 27216702 Free PMC article.

3

Contribution of Antibody Hydrodynamic Size to Vitreal Clearance Revealed through Rabbit Studies Using a Species-Matched Fab.

Shatz W, Hass PE, Mathieu M, Kim HS, Leach K, Zhou M, Crawford Y, Shen A, Wang K, Chang DP, Maia M, Crowell SR, Dickmann L, Scheer JM, Kelley RF. Shatz W, et al. Among authors: crowell sr. Mol Pharm. 2016 Sep 6;13(9):2996-3003. doi: 10.1021/acs.molpharmaceut.6b00345. Epub 2016 Jun 14. Mol Pharm. 2016. PMID: 27244474

4

Identification and characterization of an octameric PEG-protein conjugate system for intravitreal long-acting delivery to the back of the eye.

Shatz W, Hass PE, Peer N, Paluch MT, Blanchette C, Han G, Sandoval W, Morando A, Loyet KM, Bantseev V, Booler H, Crowell S, Kamath A, Scheer JM, Kelley RF. Shatz W, et al. PLoS One. 2019 Jun 28;14(6):e0218613. doi: 10.1371/journal.pone.0218613. eCollection 2019. PLoS One. 2019. PMID: 31251757 Free PMC article.

5

Hyaluronic Acid-Antibody Fragment Bioconjugates for Extended Ocular Pharmacokinetics.

Famili A, Crowell SR, Loyet KM, Mandikian D, Boswell CA, Cain D, Chan J, Comps-Agrar L, Kamath A, Rajagopal K. Famili A, et al. Among authors: crowell sr. Bioconjug Chem. 2019 Nov 20;30(11):2782-2789. doi: 10.1021/acs.bioconjchem.9b00475. Epub 2019 Oct 11. Bioconjug Chem. 2019. PMID: 31553572

6

Influence of Charge, Hydrophobicity, and Size on Vitreous Pharmacokinetics of Large Molecules.

Crowell SR, Wang K, Famili A, Shatz W, Loyet KM, Chang V, Liu Y, Prabhu S, Kamath AV, Kelley RF. Crowell SR, et al. Transl Vis Sci Technol. 2019 Nov 1;8(6):1. doi: 10.1167/tvst.8.6.1. eCollection 2019 Nov. Transl Vis Sci Technol. 2019. PMID: 31695962 Free PMC article.

7

Retinal and Lens Degeneration in New Zealand White Rabbits Administered Intravitreal TSG-6 Link Domain-Rabbit FAb Fusion Proteins.

Laing ST, Tassew N, Tesar D, Wang Y, Crowell SR, Gray J, Kwong M, Loyet KM, Andaya R, Kusi A, Kelley RF. Laing ST, et al. Among authors: crowell sr. Toxicol Pathol. 2021 Apr;49(3):634-646. doi: 10.1177/0192623320969124. Epub 2020 Dec 21. Toxicol Pathol. 2021. PMID: 33349160

8

Translational Approaches for Brain Delivery of Biologics via Cerebrospinal Fluid.

Sadekar SS, Bowen M, Cai H, Jamalian S, Rafidi H, Shatz-Binder W, Lafrance-Vanasse J, Chan P, Meilandt WJ, Oldendorp A, Sreedhara A, Daugherty A, Crowell S, Wildsmith KR, Atwal J, Fuji RN, Horvath J. Sadekar SS, et al. Clin Pharmacol Ther. 2022 Apr;111(4):826-834. doi: 10.1002/cpt.2531. Epub 2022 Feb 23. Clin Pharmacol Ther. 2022. PMID: 35064573 Free PMC article. Review.

9

Generation of a Porcine Antibody Fab Fragment Using Protein Engineering to Facilitate the Evaluation of Ocular Sustained Delivery Technology.

Kelley RF, Tesar DB, Wang Y, Agard NJ, Holder PG, Chan J, Comps-Agrar L, Horvath J, Horvath JD, Crowell SR. Kelley RF, et al. Among authors: crowell sr. Mol Pharm. 2022 May 2;19(5):1540-1547. doi: 10.1021/acs.molpharmaceut.2c00048. Epub 2022 Apr 8. Mol Pharm. 2022. PMID: 35393854

10

Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics.

Chu PY, Wang H, Ross E, Stephens N, Zhang HM, Andersen N, Chan W, Shivva V, Crowell SR, Spiess C, Holder PG, Agard NJ, Ji C, Chen J, Sreedhara A, Wang J, Wu C, Liu Y, Tran JC. Chu PY, et al. Among authors: crowell sr. Anal Chem. 2023 Dec 12;95(49):17957-17961. doi: 10.1021/acs.analchem.3c02133. Epub 2023 Nov 30. Anal Chem. 2023. PMID: 38084380

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