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Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies.
Patkar S, Heselmeyer-Haddad K, Auslander N, Hirsch D, Camps J, Bronder D, Brown M, Chen WD, Lokanga R, Wangsa D, Wangsa D, Hu Y, Lischka A, Braun R, Emons G, Ghadimi BM, Gaedcke J, Grade M, Montagna C, Lazebnik Y, Difilippantonio MJ, Habermann JK, Auer G, Ruppin E, Ried T. Patkar S, et al. Among authors: braun r. Genome Med. 2021 May 25;13(1):93. doi: 10.1186/s13073-021-00905-y. Genome Med. 2021. PMID: 34034815 Free PMC article.
The evolution of single cell-derived colorectal cancer cell lines is dominated by the continued selection of tumor-specific genomic imbalances, despite random chromosomal instability.
Wangsa D, Braun R, Schiefer M, Gertz EM, Bronder D, Quintanilla I, Padilla-Nash HM, Torres I, Hunn C, Warner L, Buishand FO, Hu Y, Hirsch D, Gaiser T, Camps J, Schwartz R, Schäffer AA, Heselmeyer-Haddad K, Ried T. Wangsa D, et al. Among authors: braun r. Carcinogenesis. 2018 Jul 30;39(8):993-1005. doi: 10.1093/carcin/bgy068. Carcinogenesis. 2018. PMID: 29800151 Free PMC article.
Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells.
Wangsa D, Braun R, Stuelten CH, Brown M, Bauer KM, Emons G, Weston LA, Hu Y, Yang HH, Vila-Casadesús M, Lee MP, Brauer P, Warner L, Upender M, Hummon AB, Camps J, Ried T. Wangsa D, et al. Among authors: braun r. Neoplasia. 2019 Jul;21(7):721-729. doi: 10.1016/j.neo.2019.04.009. Epub 2019 Jun 4. Neoplasia. 2019. PMID: 31174021 Free PMC article.
Single-Cell-Derived Primary Rectal Carcinoma Cell Lines Reflect Intratumor Heterogeneity Associated with Treatment Response.
Braun R, Anthuber L, Hirsch D, Wangsa D, Lack J, McNeil NE, Heselmeyer-Haddad K, Torres I, Wangsa D, Brown MA, Tubbs A, Auslander N, Gertz EM, Brauer PR, Cam MC, Sackett DL, Habermann JK, Nussenzweig A, Ruppin E, Zhang Z, Rosenberg DW, Ried T. Braun R, et al. Clin Cancer Res. 2020 Jul 1;26(13):3468-3480. doi: 10.1158/1078-0432.CCR-19-1984. Epub 2020 Apr 6. Clin Cancer Res. 2020. PMID: 32253233 Free PMC article.
Molecular profiling and specific targeting of gemcitabine-resistant subclones in heterogeneous pancreatic cancer cell populations.
Färber B, Lapshyna O, Künstner A, Kohl M, Sauer T, Bichmann K, Heckelmann B, Watzelt J, Honselmann K, Bolm L, Ten Winkel M, Busch H, Ungefroren H, Keck T, Gemoll T, Wellner UF, Braun R. Färber B, et al. Among authors: braun r. Front Oncol. 2023 Aug 31;13:1230382. doi: 10.3389/fonc.2023.1230382. eCollection 2023. Front Oncol. 2023. PMID: 37719017 Free PMC article.
Establishment and Molecular Characterization of Two Patient-Derived Pancreatic Ductal Adenocarcinoma Cell Lines as Preclinical Models for Treatment Response.
Braun R, Lapshyna O, Watzelt J, Drenckhan M, Künstner A, Färber B, Hael AAM, Bolm L, Honselmann KC, Konukiewitz B, Castven D, Spielmann M, Gorantla SP, Busch H, Marquardt JU, Keck T, Wellner UF, Ungefroren H. Braun R, et al. Cells. 2023 Feb 11;12(4):587. doi: 10.3390/cells12040587. Cells. 2023. PMID: 36831254 Free PMC article.
Author Correction: Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19.
Bailey JI, Puritz CH, Senkow KJ, Markov NS, Diaz E, Jonasson E, Yu Z, Swaminathan S, Lu Z, Fenske S, Grant RA, Abdala-Valencia H, Mylvaganam RJ, Ludwig A, Miller J, Cumming RI, Tighe RM, Gowdy KM, Kalhan R, Jain M, Bharat A, Kurihara C, San Jose Estepar R, San Jose Estepar R, Washko GR, Shilatifard A, Sznajder JI, Ridge KM, Budinger GRS, Braun R, Misharin AV, Sala MA. Bailey JI, et al. Among authors: braun r. Nat Immunol. 2025 Jan 7. doi: 10.1038/s41590-025-02076-z. Online ahead of print. Nat Immunol. 2025. PMID: 39774409 No abstract available.
1,481 results