Holzer M - Search Results

1

Evaluation of Novel Substituted Furopyridines as Inhibitors of Protein Kinases Related to Tau Pathology in Alzheimer´s Disease.

Schade N, Koch P, Ansideri F, Krystof V, Holzer M, Hilgeroth A. Schade N, et al. Among authors: holzer m. Med Chem. 2021;17(8):844-855. doi: 10.2174/1573406417666210601144510. Med Chem. 2021. PMID: 34061007

2

Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases.

Tell V, Holzer M, Herrmann L, Mahmoud KA, Schächtele C, Totzke F, Hilgeroth A. Tell V, et al. Among authors: holzer m. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6914-8. doi: 10.1016/j.bmcl.2012.09.006. Epub 2012 Sep 13. Bioorg Med Chem Lett. 2012. PMID: 23039927

3

Brain hypometabolism triggers PHF-like phosphorylation of tau, a major hallmark of Alzheimer's disease pathology.

Arendt T, Stieler J, Holzer M. Arendt T, et al. Among authors: holzer m. J Neural Transm (Vienna). 2015 Apr;122(4):531-9. doi: 10.1007/s00702-014-1342-8. Epub 2014 Dec 6. J Neural Transm (Vienna). 2015. PMID: 25480630 Review.

4

Drug Development of Small-Molecule Inhibitors of AD-Relevant Kinases as Novel Perspective Multitargeted Approach.

Tell V, Hilbrich I, Holzer M, Totzke F, Schachtele C, Slynko I, Sippl W, Hilgeroth A. Tell V, et al. Among authors: holzer m. Curr Alzheimer Res. 2016;13(12):1330-1336. doi: 10.2174/1567205013666160615091821. Curr Alzheimer Res. 2016. PMID: 27306698 Review.

5

Novel Protein Kinase Inhibitors Related to Tau Pathology Modulate Tau Protein-Self Interaction Using a Luciferase Complementation Assay.

Holzer M, Schade N, Opitz A, Hilbrich I, Stieler J, Vogel T, Neukel V, Oberstadt M, Totzke F, Schächtele C, Sippl W, Hilgeroth A. Holzer M, et al. Molecules. 2018 Sep 12;23(9):2335. doi: 10.3390/molecules23092335. Molecules. 2018. PMID: 30213139 Free PMC article.

6

Novel effective small-molecule inhibitors of protein kinases related to tau pathology in Alzheimer's disease.

Opitz A, Seitz LM, Krystof V, Baselious F, Holzer M, Sippl W, Hilgeroth A. Opitz A, et al. Among authors: holzer m. Future Med Chem. 2022 Aug;14(16):1175-1186. doi: 10.4155/fmc-2022-0061. Epub 2022 Aug 3. Future Med Chem. 2022. PMID: 35920260

7

Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease.

Arendt T, Holzer M, Grossmann A, Zedlick D, Brückner MK. Arendt T, et al. Among authors: holzer m. Neuroscience. 1995 Sep;68(1):5-18. doi: 10.1016/0306-4522(95)00146-a. Neuroscience. 1995. PMID: 7477934

8

Abnormally phosphorylated tau protein in Alzheimer's disease: heterogeneity of individual regional distribution and relationship to clinical severity.

Holzer M, Holzapfel HP, Zedlick D, Brückner MK, Arendt T. Holzer M, et al. Neuroscience. 1994 Nov;63(2):499-516. doi: 10.1016/0306-4522(94)90546-0. Neuroscience. 1994. PMID: 7891861

9

Paired helical filament-like phosphorylation of tau, deposition of beta/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A.

Arendt T, Holzer M, Fruth R, Brückner MK, Gärtner U. Arendt T, et al. Among authors: holzer m. Neuroscience. 1995 Dec;69(3):691-8. doi: 10.1016/0306-4522(95)00347-l. Neuroscience. 1995. PMID: 8596639

10

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease.

Arendt T, Rödel L, Gärtner U, Holzer M. Arendt T, et al. Among authors: holzer m. Neuroreport. 1996 Nov 25;7(18):3047-9. doi: 10.1097/00001756-199611250-00050. Neuroreport. 1996. PMID: 9116237

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