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Page 1
Potent Killing of Pseudomonas aeruginosa by an Antibody-Antibiotic Conjugate.
Kajihara KK, Pantua H, Hernandez-Barry H, Hazen M, Deshmukh K, Chiang N, Ohri R, Castellanos ER, Martin L, Matsumoto ML, Payandeh J, Storek KM, Schneider K, Smith PA, Koehler MFT, Tsai SP, Vandlen R, Loyet KM, Nakamura G, Pillow T, Seshasayee D, Kapadia SB, Hazenbos WLW. Kajihara KK, et al. Among authors: tsai sp. mBio. 2021 Jun 29;12(3):e0020221. doi: 10.1128/mBio.00202-21. Epub 2021 Jun 1. mBio. 2021. PMID: 34061593 Free PMC article.
High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers.
Ohri R, Bhakta S, Fourie-O'Donohue A, Dela Cruz-Chuh J, Tsai SP, Cook R, Wei B, Ng C, Wong AW, Bos AB, Farahi F, Bhakta J, Pillow TH, Raab H, Vandlen R, Polakis P, Liu Y, Erickson H, Junutula JR, Kozak KR. Ohri R, et al. Among authors: tsai sp. Bioconjug Chem. 2018 Feb 21;29(2):473-485. doi: 10.1021/acs.bioconjchem.7b00791. Epub 2018 Feb 9. Bioconjug Chem. 2018. PMID: 29425028
Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity.
Wei B, Gunzner-Toste J, Yao H, Wang T, Wang J, Xu Z, Chen J, Wai J, Nonomiya J, Tsai SP, Chuh J, Kozak KR, Liu Y, Yu SF, Lau J, Li G, Phillips GD, Leipold D, Kamath A, Su D, Xu K, Eigenbrot C, Steinbacher S, Ohri R, Raab H, Staben LR, Zhao G, Flygare JA, Pillow TH, Verma V, Masterson LA, Howard PW, Safina B. Wei B, et al. Among authors: tsai sp. J Med Chem. 2018 Feb 8;61(3):989-1000. doi: 10.1021/acs.jmedchem.7b01430. Epub 2017 Dec 21. J Med Chem. 2018. PMID: 29227683
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.
Junutula JR, Raab H, Clark S, Bhakta S, Leipold DD, Weir S, Chen Y, Simpson M, Tsai SP, Dennis MS, Lu Y, Meng YG, Ng C, Yang J, Lee CC, Duenas E, Gorrell J, Katta V, Kim A, McDorman K, Flagella K, Venook R, Ross S, Spencer SD, Lee Wong W, Lowman HB, Vandlen R, Sliwkowski MX, Scheller RH, Polakis P, Mallet W. Junutula JR, et al. Among authors: tsai sp. Nat Biotechnol. 2008 Aug;26(8):925-32. doi: 10.1038/nbt.1480. Epub 2008 Jul 20. Nat Biotechnol. 2008. PMID: 18641636
214 results