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Page 1
The chemistry and biology of soluble guanylate cyclase stimulators and activators.
Follmann M, Griebenow N, Hahn MG, Hartung I, Mais FJ, Mittendorf J, Schäfer M, Schirok H, Stasch JP, Stoll F, Straub A. Follmann M, et al. Among authors: hahn mg. Angew Chem Int Ed Engl. 2013 Sep 2;52(36):9442-62. doi: 10.1002/anie.201302588. Epub 2013 Aug 20. Angew Chem Int Ed Engl. 2013. PMID: 23963798 Review.
Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042).
Hahn MG, Lampe T, El Sheikh S, Griebenow N, Woltering E, Schlemmer KH, Dietz L, Gerisch M, Wunder F, Becker-Pelster EM, Mondritzki T, Tinel H, Knorr A, Kern A, Lang D, Hueser J, Schomber T, Benardeau A, Eitner F, Truebel H, Mittendorf J, Kumar V, van den Akker F, Schaefer M, Geiss V, Sandner P, Stasch JP. Hahn MG, et al. J Med Chem. 2021 May 13;64(9):5323-5344. doi: 10.1021/acs.jmedchem.0c02154. Epub 2021 Apr 19. J Med Chem. 2021. PMID: 33872507 Free article.
Runcaciguat, a novel soluble guanylate cyclase activator, shows renoprotection in hypertensive, diabetic, and metabolic preclinical models of chronic kidney disease.
Bénardeau A, Kahnert A, Schomber T, Meyer J, Pavkovic M, Kretschmer A, Lawrenz B, Hartmann E, Mathar I, Hueser J, Kraehling JR, Eitner F, Hahn MG, Stasch JP, Sandner P. Bénardeau A, et al. Among authors: hahn mg. Naunyn Schmiedebergs Arch Pharmacol. 2021 Dec;394(12):2363-2379. doi: 10.1007/s00210-021-02149-4. Epub 2021 Sep 22. Naunyn Schmiedebergs Arch Pharmacol. 2021. PMID: 34550407 Free PMC article.
Soluble GC stimulators and activators: Past, present and future.
Sandner P, Follmann M, Becker-Pelster E, Hahn MG, Meier C, Freitas C, Roessig L, Stasch JP. Sandner P, et al. Among authors: hahn mg. Br J Pharmacol. 2024 Nov;181(21):4130-4151. doi: 10.1111/bph.15698. Epub 2021 Dec 1. Br J Pharmacol. 2024. PMID: 34600441 Review.
Inhaled mosliciguat (BAY 1237592): targeting pulmonary vasculature via activating apo-sGC.
Becker-Pelster EM, Hahn MG, Delbeck M, Dietz L, Hüser J, Kopf J, Kraemer T, Marquardt T, Mondritzki T, Nagelschmitz J, Nikkho SM, Pires PV, Tinel H, Weimann G, Wunder F, Sandner P, Schuhmacher J, Stasch JP, Truebel HKF. Becker-Pelster EM, et al. Among authors: hahn mg. Respir Res. 2022 Oct 1;23(1):272. doi: 10.1186/s12931-022-02189-1. Respir Res. 2022. PMID: 36183104 Free PMC article.
The sGC Activator Runcaciguat Has Kidney Protective Effects and Prevents a Decline of Kidney Function in ZSF1 Rats.
Kraehling JR, Benardeau A, Schomber T, Popp L, Vienenkoetter J, Ellinger-Ziegelbauer H, Pavkovic M, Hartmann E, Siudak K, Freyberger A, Hagelschuer I, Mathar I, Hueser J, Hahn MG, Geiss V, Eitner F, Sandner P. Kraehling JR, et al. Among authors: hahn mg. Int J Mol Sci. 2023 Aug 25;24(17):13226. doi: 10.3390/ijms241713226. Int J Mol Sci. 2023. PMID: 37686032 Free PMC article.
149 results