Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice.
Schäfer A, Martinez DR, Won JJ, Meganck RM, Moreira FR, Brown AJ, Gully KL, Zweigart MR, Conrad WS, May SR, Dong S, Kalla R, Chun K, Du Pont V, Babusis D, Tang J, Murakami E, Subramanian R, Barrett KT, Bleier BJ, Bannister R, Feng JY, Bilello JP, Cihlar T, Mackman RL, Montgomery SA, Baric RS, Sheahan TP.
Schäfer A, et al. Among authors: won jj.
Sci Transl Med. 2022 May 4;14(643):eabm3410. doi: 10.1126/scitranslmed.abm3410. Epub 2022 May 4.
Sci Transl Med. 2022.
PMID: 35315683
Free PMC article.