Alessi DR - Search Results

1

R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils.

Fan Y, Nirujogi RS, Garrido A, Ruiz-Martínez J, Bergareche-Yarza A, Mondragón-Rezola E, Vinagre-Aragón A, Croitoru I, Gorostidi Pagola A, Paternain Markinez L, Alcalay R, Hickman RA, Düring J, Gomes S, Pratuseviciute N, Padmanabhan S, Valldeoriola F, Pérez Sisqués L, Malagelada C, Ximelis T, Molina Porcel L, Martí MJ, Tolosa E, Alessi DR, Sammler EM. Fan Y, et al. Among authors: alessi dr. Acta Neuropathol. 2021 Sep;142(3):475-494. doi: 10.1007/s00401-021-02325-z. Epub 2021 Jun 14. Acta Neuropathol. 2021. PMID: 34125248 Free PMC article.

2

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.

Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, Knebel A, Alessi DR. Jaleel M, et al. Among authors: alessi dr. Biochem J. 2007 Jul 15;405(2):307-17. doi: 10.1042/BJ20070209. Biochem J. 2007. PMID: 17447891 Free PMC article.

3

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.

Nichols RJ, Dzamko N, Hutti JE, Cantley LC, Deak M, Moran J, Bamborough P, Reith AD, Alessi DR. Nichols RJ, et al. Among authors: alessi dr. Biochem J. 2009 Oct 23;424(1):47-60. doi: 10.1042/BJ20091035. Biochem J. 2009. PMID: 19740074 Free PMC article.

4

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.

Dzamko N, Deak M, Hentati F, Reith AD, Prescott AR, Alessi DR, Nichols RJ. Dzamko N, et al. Among authors: alessi dr. Biochem J. 2010 Sep 15;430(3):405-13. doi: 10.1042/BJ20100784. Biochem J. 2010. PMID: 20659021 Free PMC article.

5

Characterization of TAE684 as a potent LRRK2 kinase inhibitor.

Zhang J, Deng X, Choi HG, Alessi DR, Gray NS. Zhang J, et al. Among authors: alessi dr. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1864-9. doi: 10.1016/j.bmcl.2012.01.084. Epub 2012 Jan 28. Bioorg Med Chem Lett. 2012. PMID: 22335897 Free PMC article.

6

Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies.

Davies P, Hinkle KM, Sukar NN, Sepulveda B, Mesias R, Serrano G, Alessi DR, Beach TG, Benson DL, White CL, Cowell RM, Das SS, West AB, Melrose HL. Davies P, et al. Among authors: alessi dr. Biochem J. 2013 Jul 1;453(1):101-13. doi: 10.1042/BJ20121742. Biochem J. 2013. PMID: 23560750 Free PMC article.

7

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

Steger M, Tonelli F, Ito G, Davies P, Trost M, Vetter M, Wachter S, Lorentzen E, Duddy G, Wilson S, Baptista MA, Fiske BK, Fell MJ, Morrow JA, Reith AD, Alessi DR, Mann M. Steger M, et al. Among authors: alessi dr. Elife. 2016 Jan 29;5:e12813. doi: 10.7554/eLife.12813. Elife. 2016. PMID: 26824392 Free PMC article.

8

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.

Ito G, Katsemonova K, Tonelli F, Lis P, Baptista MA, Shpiro N, Duddy G, Wilson S, Ho PW, Ho SL, Reith AD, Alessi DR. Ito G, et al. Among authors: alessi dr. Biochem J. 2016 Sep 1;473(17):2671-85. doi: 10.1042/BCJ20160557. Epub 2016 Jul 29. Biochem J. 2016. PMID: 27474410 Free PMC article.

9

Small-Molecule Inhibitors of LRRK2.

Hatcher JM, Choi HG, Alessi DR, Gray NS. Hatcher JM, et al. Among authors: alessi dr. Adv Neurobiol. 2017;14:241-264. doi: 10.1007/978-3-319-49969-7_13. Adv Neurobiol. 2017. PMID: 28353288 Review.

10

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M. Steger M, et al. Among authors: alessi dr. Elife. 2017 Nov 10;6:e31012. doi: 10.7554/eLife.31012. Elife. 2017. PMID: 29125462 Free PMC article.

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