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In Vitro Activity and Microbiological Efficacy of Gepotidacin from a Phase 2, Randomized, Multicenter, Dose-Ranging Study in Patients with Acute Bacterial Skin and Skin Structure Infections.
Scangarella-Oman NE, Ingraham KA, Tiffany CA, Tomsho L, Van Horn SF, Mayhew DN, Perry CR, Ashton TC, Dumont EF, Huang J, Brown JR, Miller LA. Scangarella-Oman NE, et al. Among authors: brown jr. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01302-19. doi: 10.1128/AAC.01302-19. Print 2020 Feb 21. Antimicrob Agents Chemother. 2020. PMID: 31818823 Free PMC article.
Correction to: Microbiome recovery in adult females with uncomplicated urinary tract infections in a randomised phase 2A trial of the novel antibiotic gepotidacin (GSK2140944).
Nuzzo A, Van Horn S, Traini C, Perry CR, Dumont EF, Scangarella-Oman NE, Gardiner DF, Brown JR. Nuzzo A, et al. Among authors: brown jr. BMC Microbiol. 2021 Oct 26;21(1):293. doi: 10.1186/s12866-021-02356-2. BMC Microbiol. 2021. PMID: 34702186 Free PMC article. No abstract available.
Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections.
O'Dwyer K, Spivak AT, Ingraham K, Min S, Holmes DJ, Jakielaszek C, Rittenhouse S, Kwan AL, Livi GP, Sathe G, Thomas E, Van Horn S, Miller LA, Twynholm M, Tomayko J, Dalessandro M, Caltabiano M, Scangarella-Oman NE, Brown JR. O'Dwyer K, et al. Among authors: brown jr. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. doi: 10.1128/AAC.03774-14. Epub 2014 Oct 27. Antimicrob Agents Chemother. 2015. PMID: 25348524 Free PMC article. Clinical Trial.
Microbiome changes in healthy volunteers treated with GSK1322322, a novel antibiotic targeting bacterial peptide deformylase.
Arat S, Spivak A, Van Horn S, Thomas E, Traini C, Sathe G, Livi GP, Ingraham K, Jones L, Aubart K, Holmes DJ, Naderer O, Brown JR. Arat S, et al. Among authors: brown jr. Antimicrob Agents Chemother. 2015 Feb;59(2):1182-92. doi: 10.1128/AAC.04506-14. Epub 2014 Dec 8. Antimicrob Agents Chemother. 2015. PMID: 25487798 Free PMC article. Clinical Trial.
The Microbiome Factor in Drug Discovery and Development.
Nuzzo A, Brown JR. Nuzzo A, et al. Among authors: brown jr. Chem Res Toxicol. 2020 Jan 21;33(1):119-124. doi: 10.1021/acs.chemrestox.9b00333. Epub 2019 Dec 23. Chem Res Toxicol. 2020. PMID: 31802667 Review.
Microbiome Metabolite Mimics Accelerate Drug Discovery.
Nuzzo A, Brown JR. Nuzzo A, et al. Among authors: brown jr. Trends Mol Med. 2020 May;26(5):435-437. doi: 10.1016/j.molmed.2020.03.006. Epub 2020 Apr 3. Trends Mol Med. 2020. PMID: 32359474
3,898 results