Edginton AN - Search Results

1

Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population.

Salerno SN, Carreño FO, Edginton AN, Cohen-Wolkowiez M, Gonzalez D. Salerno SN, et al. Among authors: edginton an. Drug Metab Dispos. 2021 Sep;49(9):844-855. doi: 10.1124/dmd.120.000318. Epub 2021 Jun 21. Drug Metab Dispos. 2021. PMID: 34154994 Free PMC article.

2

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development.

Edginton AN, Theil FP, Schmitt W, Willmann S. Edginton AN, et al. Expert Opin Drug Metab Toxicol. 2008 Sep;4(9):1143-52. doi: 10.1517/17425255.4.9.1143. Expert Opin Drug Metab Toxicol. 2008. PMID: 18721109 Review.

3

Simulation of differential drug pharmacokinetics under heat and exercise stress using a physiologically based pharmacokinetic modeling approach.

Sidhu P, Peng HT, Cheung B, Edginton A. Sidhu P, et al. Can J Physiol Pharmacol. 2011 May;89(5):365-82. doi: 10.1139/y11-030. Epub 2011 May 31. Can J Physiol Pharmacol. 2011. PMID: 21627485

4

Physiologically based pharmacokinetic modeling and simulation in pediatric drug development.

Maharaj AR, Edginton AN. Maharaj AR, et al. Among authors: edginton an. CPT Pharmacometrics Syst Pharmacol. 2014 Oct 22;3(11):e150. doi: 10.1038/psp.2014.45. CPT Pharmacometrics Syst Pharmacol. 2014. PMID: 25353188 Free PMC article.

5

Examining Small Intestinal Transit Time as a Function of Age: Is There Evidence to Support Age-Dependent Differences among Children?

Maharaj AR, Edginton AN. Maharaj AR, et al. Among authors: edginton an. Drug Metab Dispos. 2016 Jul;44(7):1080-9. doi: 10.1124/dmd.115.068700. Epub 2016 Mar 14. Drug Metab Dispos. 2016. PMID: 26977099 Review.

6

Development of a Pediatric Physiologically-Based Pharmacokinetic Model of Clindamycin Using Opportunistic Pharmacokinetic Data.

Hornik CP, Wu H, Edginton AN, Watt K, Cohen-Wolkowiez M, Gonzalez D. Hornik CP, et al. Among authors: edginton an. Clin Pharmacokinet. 2017 Nov;56(11):1343-1353. doi: 10.1007/s40262-017-0525-5. Clin Pharmacokinet. 2017. PMID: 28290120 Free PMC article.

7

Improving Pediatric Protein Binding Estimates: An Evaluation of α1-Acid Glycoprotein Maturation in Healthy and Infected Subjects.

Maharaj AR, Gonzalez D, Cohen-Wolkowiez M, Hornik CP, Edginton AN. Maharaj AR, et al. Among authors: edginton an. Clin Pharmacokinet. 2018 May;57(5):577-589. doi: 10.1007/s40262-017-0576-7. Clin Pharmacokinet. 2018. PMID: 28779462 Free PMC article.

8

Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid.

Salerno SN, Edginton A, Cohen-Wolkowiez M, Hornik CP, Watt KM, Jamieson BD, Gonzalez D. Salerno SN, et al. CPT Pharmacometrics Syst Pharmacol. 2017 Dec;6(12):814-822. doi: 10.1002/psp4.12252. Epub 2017 Oct 25. CPT Pharmacometrics Syst Pharmacol. 2017. PMID: 29068158 Free PMC article.

9

Pediatric physiology in relation to the pharmacokinetics of monoclonal antibodies.

Malik P, Edginton A. Malik P, et al. Expert Opin Drug Metab Toxicol. 2018 Jun;14(6):585-599. doi: 10.1080/17425255.2018.1482278. Epub 2018 Jun 4. Expert Opin Drug Metab Toxicol. 2018. PMID: 29806953 Review.

10

Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO.

Watt KM, Cohen-Wolkowiez M, Barrett JS, Sevestre M, Zhao P, Brouwer KLR, Edginton AN. Watt KM, et al. Among authors: edginton an. CPT Pharmacometrics Syst Pharmacol. 2018 Oct;7(10):629-637. doi: 10.1002/psp4.12338. Epub 2018 Aug 13. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 30033691 Free PMC article.

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