Fashe M - Search Results

1

Sex-specific expression mechanism of hepatic estrogen inactivating enzyme and transporters in diabetic women.

Fashe M, Yi M, Sueyoshi T, Negishi M. Fashe M, et al. Biochem Pharmacol. 2021 Aug;190:114662. doi: 10.1016/j.bcp.2021.114662. Epub 2021 Jun 23. Biochem Pharmacol. 2021. PMID: 34157297 Free PMC article.

2

Phenobarbital-induced phosphorylation converts nuclear receptor RORα from a repressor to an activator of the estrogen sulfotransferase gene Sult1e1 in mouse livers.

Fashe M, Hashiguchi T, Yi M, Moore R, Negishi M. Fashe M, et al. FEBS Lett. 2018 Aug;592(16):2760-2768. doi: 10.1002/1873-3468.13199. Epub 2018 Aug 10. FEBS Lett. 2018. PMID: 30025153 Free PMC article.

3

Ser100-Phosphorylated RORα Orchestrates CAR and HNF4α to Form Active Chromatin Complex in Response to Phenobarbital to Regulate Induction of CYP2B6.

Fashe M, Hashiguchi T, Negishi M, Sueyoshi T. Fashe M, et al. Mol Pharmacol. 2020 Mar;97(3):191-201. doi: 10.1124/mol.119.118273. Epub 2020 Jan 10. Mol Pharmacol. 2020. PMID: 31924695 Free PMC article.

4

Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver.

Yi M, Fashe M, Arakawa S, Moore R, Sueyoshi T, Negishi M. Yi M, et al. Among authors: fashe m. Sci Rep. 2020 Mar 19;10(1):5001. doi: 10.1038/s41598-020-61767-9. Sci Rep. 2020. PMID: 32193417 Free PMC article.

5

A phosphorylation-deficient mutant of retinoid X receptor α at Thr 167 alters fasting response and energy metabolism in mice.

Sueyoshi T, Sakuma T, Shindo S, Fashe M, Kanayama T, Ray M, Moore R, Negishi M. Sueyoshi T, et al. Among authors: fashe m. Lab Invest. 2019 Oct;99(10):1470-1483. doi: 10.1038/s41374-019-0266-1. Epub 2019 May 31. Lab Invest. 2019. PMID: 31152145 Free PMC article.

6

In vitro sulfonation of 7-hydroxycoumarin derivatives in liver cytosol of human and six animal species.

Juvonen RO, Pentikäinen O, Huuskonen J, Timonen J, Kärkkäinen O, Heikkinen A, Fashe M, Raunio H. Juvonen RO, et al. Among authors: fashe m. Xenobiotica. 2020 Aug;50(8):885-893. doi: 10.1080/00498254.2020.1711544. Epub 2020 Jan 8. Xenobiotica. 2020. PMID: 31903849 Free PMC article.

7

Species-Specific Differences in the in Vitro Metabolism of Lasiocarpine.

Fashe MM, Juvonen RO, Petsalo A, Räsänen J, Pasanen M. Fashe MM, et al. Chem Res Toxicol. 2015 Oct 19;28(10):2034-44. doi: 10.1021/acs.chemrestox.5b00253. Epub 2015 Oct 2. Chem Res Toxicol. 2015. PMID: 26395423

8

Rational design of novel CYP2A6 inhibitors.

Tani N, Juvonen RO, Raunio H, Fashe M, Leppänen J, Zhao B, Tyndale RF, Rahnasto-Rilla M. Tani N, et al. Among authors: fashe m. Bioorg Med Chem. 2014 Dec 1;22(23):6655-6664. doi: 10.1016/j.bmc.2014.10.001. Epub 2014 Oct 13. Bioorg Med Chem. 2014. PMID: 25458499

9

In silico prediction of the site of oxidation by cytochrome P450 3A4 that leads to the formation of the toxic metabolites of pyrrolizidine alkaloids.

Fashe MM, Juvonen RO, Petsalo A, Vepsäläinen J, Pasanen M, Rahnasto-Rilla M. Fashe MM, et al. Chem Res Toxicol. 2015 Apr 20;28(4):702-10. doi: 10.1021/tx500478q. Epub 2015 Feb 17. Chem Res Toxicol. 2015. PMID: 25651456

10

Identification of a new reactive metabolite of pyrrolizidine alkaloid retrorsine: (3H-pyrrolizin-7-yl)methanol.

Fashe MM, Juvonen RO, Petsalo A, Rahnasto-Rilla M, Auriola S, Soininen P, Vepsäläinen J, Pasanen M. Fashe MM, et al. Chem Res Toxicol. 2014 Nov 17;27(11):1950-7. doi: 10.1021/tx5002964. Epub 2014 Oct 21. Chem Res Toxicol. 2014. PMID: 25295702

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