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The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody.
Chan CEZ, Seah SGK, Chye H, Massey S, Torres M, Lim APC, Wong SKK, Neo JJY, Wong PS, Lim JH, Loh GSL, Wang D, Boyd-Kirkup JD, Guan S, Thakkar D, Teo GH, Purushotorman K, Hutchinson PE, Young BE, Low JG, MacAry PA, Hentze H, Prativadibhayankara VS, Ethirajulu K, Comer JE, Tseng CK, Barrett ADT, Ingram PJ, Brasel T, Hanson BJ. Chan CEZ, et al. Among authors: young be. PLoS One. 2021 Jun 23;16(6):e0253487. doi: 10.1371/journal.pone.0253487. eCollection 2021. PLoS One. 2021. PMID: 34161386 Free PMC article.
Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore.
Young BE, Ong SWX, Kalimuddin S, Low JG, Tan SY, Loh J, Ng OT, Marimuthu K, Ang LW, Mak TM, Lau SK, Anderson DE, Chan KS, Tan TY, Ng TY, Cui L, Said Z, Kurupatham L, Chen MI, Chan M, Vasoo S, Wang LF, Tan BH, Lin RTP, Lee VJM, Leo YS, Lye DC; Singapore 2019 Novel Coronavirus Outbreak Research Team. Young BE, et al. JAMA. 2020 Apr 21;323(15):1488-1494. doi: 10.1001/jama.2020.3204. JAMA. 2020. PMID: 32125362 Free PMC article.
Testing for SARS-CoV-2: Can We Stop at 2?
Lee TH, Junhao Lin R, Lin RTP, Barkham T, Rao P, Leo YS, Chien Lye D, Young B; National Centre for Infectious Diseases COVID-19 Outbreak Research Team. Lee TH, et al. Clin Infect Dis. 2020 Nov 19;71(16):2246-2248. doi: 10.1093/cid/ciaa459. Clin Infect Dis. 2020. PMID: 32306042 Free PMC article.
Lack of cross-neutralization by SARS patient sera towards SARS-CoV-2.
Anderson DE, Tan CW, Chia WN, Young BE, Linster M, Low JH, Tan YJ, Chen MI, Smith GJD, Leo YS, Lye DC, Wang LF. Anderson DE, et al. Among authors: young be. Emerg Microbes Infect. 2020 Dec;9(1):900-902. doi: 10.1080/22221751.2020.1761267. Emerg Microbes Infect. 2020. PMID: 32380903 Free PMC article.
Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients.
Poh CM, Carissimo G, Wang B, Amrun SN, Lee CY, Chee RS, Fong SW, Yeo NK, Lee WH, Torres-Ruesta A, Leo YS, Chen MI, Tan SY, Chai LYA, Kalimuddin S, Kheng SSG, Thien SY, Young BE, Lye DC, Hanson BJ, Wang CI, Renia L, Ng LFP. Poh CM, et al. Among authors: young be. Nat Commun. 2020 Jun 1;11(1):2806. doi: 10.1038/s41467-020-16638-2. Nat Commun. 2020. PMID: 32483236 Free PMC article.
Serological differentiation between COVID-19 and SARS infections.
Chia WN, Tan CW, Foo R, Kang AEZ, Peng Y, Sivalingam V, Tiu C, Ong XM, Zhu F, Young BE, Chen MI, Tan YJ, Lye DC, Anderson DE, Wang LF. Chia WN, et al. Among authors: young be. Emerg Microbes Infect. 2020 Dec;9(1):1497-1505. doi: 10.1080/22221751.2020.1780951. Emerg Microbes Infect. 2020. PMID: 32529906 Free PMC article. Clinical Trial.
Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2.
Su YCF, Anderson DE, Young BE, Linster M, Zhu F, Jayakumar J, Zhuang Y, Kalimuddin S, Low JGH, Tan CW, Chia WN, Mak TM, Octavia S, Chavatte JM, Lee RTC, Pada S, Tan SY, Sun L, Yan GZ, Maurer-Stroh S, Mendenhall IH, Leo YS, Lye DC, Wang LF, Smith GJD. Su YCF, et al. Among authors: young be. mBio. 2020 Jul 21;11(4):e01610-20. doi: 10.1128/mBio.01610-20. mBio. 2020. PMID: 32694143 Free PMC article.
Linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity.
Amrun SN, Lee CY, Lee B, Fong SW, Young BE, Chee RS, Yeo NK, Torres-Ruesta A, Carissimo G, Poh CM, Chang ZW, Tay MZ, Chan YH, Chen MI, Low JG, Tambyah PA, Kalimuddin S, Pada S, Tan SY, Sun LJ, Leo YS, Lye DC, Renia L, Ng LFP. Amrun SN, et al. Among authors: young be. EBioMedicine. 2020 Aug;58:102911. doi: 10.1016/j.ebiom.2020.102911. Epub 2020 Jul 22. EBioMedicine. 2020. PMID: 32711254 Free PMC article.
273 results